Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IN-VIVO MAGNETIC-RESONANCE SPECTROSCOPY OF HUMAN BRAIN - THE BIOPHYSICAL BASIS OF DEMENTIA
Autore:
ROSS BD; BLUML S; COWAN R; DANIELSEN E; FARROW N; GRUETTER R;
Indirizzi:
HUNTINGTON MED RES INST PASADENA CA 91105
Titolo Testata:
Biophysical chemistry
fascicolo: 1-3, volume: 68, anno: 1997,
pagine: 161 - 172
SICI:
0301-4622(1997)68:1-3<161:IMSOHB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTON MR SPECTROSCOPY; INCREASED CEREBRAL MYOINOSITOL; CHRONIC HEPATIC-ENCEPHALOPATHY; LOCALIZED H-1-NMR SPECTRA; ENHANCED INOSITOL UPTAKE; ALZHEIMERS-DISEASE; METABOLITE CONCENTRATIONS; NMR-SPECTROSCOPY; APOLIPOPROTEIN-E; DOWN-SYNDROME;
Keywords:
NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NEURONAL MARKERS; NEUROCHEMISTRY DISORDERS; ALZHEIMER DISEASE; NEUROTRANSMITTERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
B.D. Ross et al., "IN-VIVO MAGNETIC-RESONANCE SPECTROSCOPY OF HUMAN BRAIN - THE BIOPHYSICAL BASIS OF DEMENTIA", Biophysical chemistry, 68(1-3), 1997, pp. 161-172

Abstract

Nuclear magnetic resonance spectroscopy (MRS) in low and medium magnetic fields yields well-resolved natural abundance proton and decoupledphosphorus spectra from small (1-10 cc) volumes of brain in vivo in minutes. With this tool, neurochemical research has advanced through identification and non-invasive assay of specific neuronal - (N-acetylaspartate), glial (myo-inositol) - markers, energetics and osmolytes, and neurotransmitters (glutamate, GABA), From these simple measurements,several dozen disease states are recognized, including birth injury, and white matter and Alzheimer disease. Addition of stable isotopes ofcarbon (in man) or nitrogen (in experimental animals) has provided invivo assays of enzyme flux through glucose transport, glycolysis, TCA-cycle, and the glutamine-glutamate-GABA system. Finally, a number of xenobiotics are recognized with heteronuclear NMR techniques. Together, these tools are having a major impact on neuroscience and clinical medicine. Through diagnosis and therapeutic monitoring, a new generation of in vivo metabolite imaging is expected with the advent of conforming RF coils and higher field NMR systems. (C) 1997 Elsevier Science B. V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 05:31:55