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Titolo:
GLYCINE(B) ANTAGONISTS AS POTENTIAL THERAPEUTIC AGENTS - PREVIOUS HOPES AND PRESENT REALITY
Autore:
DANYSZ W; PARSONS CG; KARCZKUBICHA M; SCHWAIER A; POPIK P; WEDZONY K; LAZAREWICZ J; QUACK G;
Indirizzi:
MERZ & CO,DEPT PHARMACOL,ECKENHEIMER LANDSTR 100-104 D-60318 FRANKFURT GERMANY POLISH ACAD SCI,INST PHARMACOL KRAKOW POLAND POLISH ACAD SCI,MED RES CTR WARSAW POLAND
Titolo Testata:
Amino acids
fascicolo: 1-3, volume: 14, anno: 1998,
pagine: 235 - 239
SICI:
0939-4451(1998)14:1-3<235:GAAPTA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONISTS; SITE; CONVULSIONS; ISCHEMIA; RATS;
Keywords:
NMDA RECEPTORS; GLUTAMATE; BEHAVIOR; MRZ 2/570; MRZ 2/576; L-701,324;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
W. Danysz et al., "GLYCINE(B) ANTAGONISTS AS POTENTIAL THERAPEUTIC AGENTS - PREVIOUS HOPES AND PRESENT REALITY", Amino acids, 14(1-3), 1998, pp. 235-239

Abstract

It is not clear what therapeutic application is most likely for agents blocking glycine site of the NMDA receptors (glycine(B)). Majority of the studies to date used either glycine(B) antagonists with doubtfulbrain penetration or partial agonists. Following systemic administration to rats of our newly developed glycine(B) antagonists (MRZ 2/570; 2/571 and 2/576) and L-701,324 (MSD) as a reference agent the following behavioural effects were observed: weak (if any) antiparkinsonian-like effects, lack of anxiolytic activity, inhibition of physical and motivational aspects of morphine dependence and neuroprotective activityin global ischaemia. The side effects include: sedation, ataxia, and myorelaxation. We detected neither vacuolisation in the cingulate cortex nor impairment of pre-pulse inhibition indicating lack of psychotomimetic potential.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:56:59