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Titolo:
THE ROLE OF STRIATAL GLUTAMATE RECEPTORS IN MODELS OF PARKINSONS-DISEASE
Autore:
OSSOWSKA K; LORENCKOCI E; KONIECZNY J; WOLFARTH S;
Indirizzi:
POLISH ACAD SCI,INST PHARMACOL,DEPT NEUROPSYCHOPHARMACOL,12 SMETNA STPL-31343 KRAKOW POLAND
Titolo Testata:
Amino acids
fascicolo: 1-3, volume: 14, anno: 1998,
pagine: 11 - 15
SICI:
0939-4451(1998)14:1-3<11:TROSGR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RIGIDITY; RATS; MK-801;
Keywords:
PARKINSONIAN-LIKE MUSCLE RIGIDITY; NMDA RECEPTOR ANTAGONISTS; STRIATUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
K. Ossowska et al., "THE ROLE OF STRIATAL GLUTAMATE RECEPTORS IN MODELS OF PARKINSONS-DISEASE", Amino acids, 14(1-3), 1998, pp. 11-15

Abstract

The aim of the study was to examine the effect of antagonists of the NMDA receptor on the parkinsonian-like muscle rigidity in rats. Reserpine and haloperidol increased the muscle resistance of the hind foot to passive movements, as well as the reflex electromyographic (EMG) activity in the gastrocnemius and tibialis anterior muscles. MK-801 (0.32-1.28 mg/kg sc), an uncompetitive antagonist of the NMDA receptor, andL-701,324 (5-40 mg/kg ip), an antagonist of the glycine site, reducedthe muscle tone and the reflex EMG activity enhanced by reserpine or haloperidol. AP-5 (2 and 5 mu g/0.5 mu l), a competitive antagonist ofthe NMDA receptor, and 5,7-dichlorokynurenic acid (1.0-4.5 mu g/0.5 mu l), the glycine site antagonist injected bilaterally into the rostral striatum, inhibited the muscle rigidity induced by haloperidol. In contrast, AP-5, injected alone bilaterally into the intermediate-caudalstriatum induced muscle rigidity. The present results suggest that: (1) the inhibitory effect of the NMDA receptor antagonists on the parkinsonian-like muscle rigidity depends, at least partly, on their actionon the rostral striatum; (2) the blockade of NMDA receptors in the intermediate-caudal striatum may reduce the beneficial impact of these compounds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:16:55