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Titolo:
LACK OF INTERACTION BETWEEN VALACICLOVIR, THE L-VALYL ESTER OF ACYCLOVIR, AND DIGOXIN
Autore:
SOULLAWTON JH; WEATHERLEY BC; POSNER J; LAYTON G; PECK RW;
Indirizzi:
GLAXO WELLCOME RES & DEV LTD GREENFORD UB6 0HE MIDDX ENGLAND GLAXO WELLCOME RES & DEV LTD BECKENHAM BR3 3BS KENT ENGLAND PFIZER LTD,CENT RES SANDWICH CT13 9NJ KENT ENGLAND
Titolo Testata:
British journal of clinical pharmacology
fascicolo: 1, volume: 45, anno: 1998,
pagine: 87 - 89
SICI:
0306-5251(1998)45:1<87:LOIBVT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Keywords:
VALACICLOVIR; DIGOXIN; NO INTERACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Soullawton et al., "LACK OF INTERACTION BETWEEN VALACICLOVIR, THE L-VALYL ESTER OF ACYCLOVIR, AND DIGOXIN", British journal of clinical pharmacology, 45(1), 1998, pp. 87-89

Abstract

Aims Changes in both digoxin and aciclovir renal clearance following coadministration with some other renally eliminated drugs have been reported. The potential interaction of valaciclovir, with its antiherpetic metabolite aciclovir, and digoxin was investigated. Methods Twelve healthy volunteers (seven males, five females) participated in an open, randomized, four-period crossover study. Valaciclovir, 1000 mg, was given alone on one occasion, and on another, after the second of two 0.75 mg digoxin doses administered 12 h apart. Blood samples and all urine were collected up to 12 h following the valaciclovir dose for aciclovir radioimmunoassay. On a third occasion, digoxin was given alone and on a fourth, with 1000 mg va]aciclovir three times/day for 8 days starting 12 h before the first digoxin dose. Blood samples were taken up to 168 h and all urine collected up to 24 h following the second dose for digoxin radioimmunoassay. Results There were no clinically significant differences in digoxin or aciclovir pharmacokinetic parameters when digoxin or valaciclovir was given alone or in combination. Conclusions No dosage adjustment is required when valaciclovir and digoxin are coadministered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:44:57