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Titolo:
EXPRESSION OF TGF-BETA SUPERFAMILY RECEPTORS IN DENTAL-PULP
Autore:
TOYONO T; NAKASHIMA M; KUHARA S; AKAMINE A;
Indirizzi:
KYUSHU UNIV,GRAD SCH GENET RESOURCES TECHNOL,LAB MOL GENE TECH,HIGASHI KU FUKUOKA 81281 JAPAN KYUSHU UNIV,FAC DENT,DEPT OPERAT DENT & ENDODONTOL,HIGASHI KU FUKUOKA81282 JAPAN
Titolo Testata:
Journal of dental research
fascicolo: 9, volume: 76, anno: 1997,
pagine: 1555 - 1560
SICI:
0022-0345(1997)76:9<1555:EOTSRI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; SERINE THREONINE KINASE; BONE MORPHOGENETIC PROTEIN-2; MESSENGER RIBONUCLEIC-ACIDS; EARLY TOOTH DEVELOPMENT; II RECEPTOR; MOLECULAR CHARACTERIZATION; OSTEOGENIC PROTEIN-1; RAT EMBRYOGENESIS; MOUSE DEVELOPMENT;
Keywords:
TRANSFORMING GROWTH FACTOR-BETA; BONE MORPHOGENETIC PROTEIN; RECEPTORS; DENTAL PULP; TOOTH DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
T. Toyono et al., "EXPRESSION OF TGF-BETA SUPERFAMILY RECEPTORS IN DENTAL-PULP", Journal of dental research, 76(9), 1997, pp. 1555-1560

Abstract

Transforming growth factor-beta (TGF-beta) superfamily members and their cell-surface receptors may play inductive and/or regulatory roles in tooth development and repair. It will be important to identify the complete set of TGF-beta superfamily receptors, to examine their temporal and spatial localization during tooth development, and to elucidate the cascade of molecular events of tooth formation induced by the TGF-beta superfamily. In this report, we have cloned the cDNAs encoding potential receptors for TGF-beta superfamily members in rat incisor pulp and bovine adult pulp which are regarded as embryonic and adult pulp, respectively. We analyzed poly (A)(+) RNA from rat incisor pulp andbovine adult pulp by reverse-transcriptase/polymerase chain-reaction (RT-PCR), using degenerate primers corresponding to the most conservedamino acid sequences in the intracellular serine/threonine kinase of type I or type II receptors. Each amplified cDNA encoding activin receptorlike kinase-l (ALK-1), ALK-2, ALK-3 (bone morphogenetic protein receptor type IA, BMPR-IA), ALK-4 (B1), ALK-5, ALK-6 (BMPR-IB), and BMPR-II (BMP type II receptor) was found to be in dental pulp. Northern blot analysis further detected TGF-beta type II receptor (T beta R-II) mRNA transcript in addition to the above-identified receptors. These results provide the first evidence of multiple type I and type II receptors for TGF-beta s, activins, and BMPs expressed in embryonic and adult pulp, implicating diverse function in tooth development and pulp tissue repair.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 06:26:24