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Titolo:
HUMAN NEUTROPHIL COLLAGENASE MMP-8 IN PERI-IMPLANT SULCUS FLUID AND ITS INHIBITION BY CLODRONATE
Autore:
TERONEN O; KONTTINEN YT; LINDQVIST C; SALO T; INGMAN T; LAUHIO A; DING Y; SANTAVIRTA S; SORSA T;
Indirizzi:
UNIV HELSINKI,INST DENT,DEPT ORAL & MAXILLOFACIAL SURG,POB 41 FIN-00014 HELSINKI FINLAND UNIV HELSINKI,INST DENT,DEPT PERINATOL FIN-00014 HELSINKI FINLAND UNIV HELSINKI,INST DENT,DEPT PEDODONT & ORTHODONT FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT MED FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT ANAT FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT ORTHOPED & TRAUMATOL,DEPT SURG FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT MED CHEM FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT ORAL & MAXILLOFACIAL SURG,DEPT SURG FIN-00014 HELSINKI FINLAND UNIV OULU,DEPT ORAL & MAXILLOFACIAL SURG OULU FINLAND UNIV OULU,DEPT PATHOL OULU FINLAND
Titolo Testata:
Journal of dental research
fascicolo: 9, volume: 76, anno: 1997,
pagine: 1529 - 1537
SICI:
0022-0345(1997)76:9<1529:HNCMIP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMORPHONUCLEAR LEUKOCYTE COLLAGENASE; MATRIX METALLOPROTEINASES; REACTIVE ARTHRITIS; CREVICULAR FLUID; INTERSTITIAL COLLAGENASES; JUVENILE PERIODONTITIS; RHEUMATOID-ARTHRITIS; CARTILAGE AGGRECAN; TETRACYCLINES; DOXYCYCLINE;
Keywords:
METALLOPROTEINASES; CLODRONATE/BISPHOSPHONATES; INHIBITION; GINGIVAL CREVICULAR FLUID; PERI-IMPLANT SULCUS FLUID;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
O. Teronen et al., "HUMAN NEUTROPHIL COLLAGENASE MMP-8 IN PERI-IMPLANT SULCUS FLUID AND ITS INHIBITION BY CLODRONATE", Journal of dental research, 76(9), 1997, pp. 1529-1537

Abstract

The exact molecular mechanisms of the loosening of a dental implant are not well-known. The characteristics of implant sulci are similar tothose of periodontal sulci regarding gingival crevicular fluid (GCF) and peri-implant sulcular fluid (PISF). Proteolytic enzymes, matrix metalloproteinases (MMPs), participate in peri-implant tissue remodeling. Clodronate is a well-tolerated bisphosphonate-group drug currently used in bone-resorption-related diseases in humans. The mechanisms of bisphosphonate action are not clarified. Collagenase activity in diseased PISF was significantly higher than in the clinically healthy group. Immunoblotting disclosed that diseased PISF contained increased immunoreactives MMP-8 compared with the healthy PISF. The residual latent collagenase activity in the diseased PISF was activated by gold thioglucose and inhibited completely by 100 mu M of doxycycline closely resembling pure neutrophil collagenase (MMP-8). The presence of MMP-8 in diseased but not in clinically healthy PISF may prove to be a useful biochemical indicator to monitor peri-implant health and disease. Pure human neutrophil collagenase (MMP-8) and the MMP-8 present in PISF and in the GCF of both loosening implants and periodontitis-affected teeth were efficiently inhibited in vitro by clodronate (50% inhibition [IC50] was achieved by 150 mu M of clodronate), an osteoactive, antiresorptive bisphosphonate. Furthermore, the new finding suggests an extendedand hitherto-undescribed potential for clodronate in preventing the loosening of both implants and teeth, based on a dual beneficial effect: prevention of both bone resorption/osteolysis and of soft tissue/dental ligament destruction. Potential new therapeutic indications based on the collagenase-inhibiting effect of clodronate provide potential new therapeutic indications for a variety of diseases involving connective tissue breakdown, such as periodontal disease, arthritides, and tumor invasion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 13:39:44