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Titolo:
TRANSDERMAL IONTOPHORETIC DELIVERY OF [H-3]GHRP IN RATS
Autore:
ELLENS H; LAI ZP; MARCELLO J; DAVIS CB; CHENG HY; OH CK; OKABE K;
Indirizzi:
SMITHKLINE BEECHAM PHARMACEUT,DEPT DRUG DELIVERY,1250 S COLLEGEVILLE RD COLLEGEVILLE PA 19426 ADVANCE CO LTD,DRUG DELIVERY SYST R&D CTR,MEGURO KU TOKYO JAPAN SMITHKLINE BEECHAM PHARMACEUT KING OF PRUSSIA PA 19406
Titolo Testata:
International journal of pharmaceutics
fascicolo: 1, volume: 159, anno: 1997,
pagine: 1 - 11
SICI:
0378-5173(1997)159:1<1:TIDO[I>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING PEPTIDE; PLASMA GROWTH-HORMONE; PENETRATION ENHANCEMENT; GH RELEASE; NORMAL MEN; INSULIN; SKIN; SK-AND-F-110679; POLYPEPTIDES; HEXAPEPTIDE;
Keywords:
GROWTH HORMONE-RELEASING PEPTIDE; H-3-GHRP; IONTOPHORESIS; PEPTIDE DELIVERY; TRANSDERMAL DELIVERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
H. Ellens et al., "TRANSDERMAL IONTOPHORETIC DELIVERY OF [H-3]GHRP IN RATS", International journal of pharmaceutics, 159(1), 1997, pp. 1-11

Abstract

In this study, we demonstrate transdermal iontophoretic delivery of radiolabeled growth hormone-releasing peptide ([H-3]GHRP, [H-3]SK&F 110679) from an iontophoretic patch delivery device in rats. [H-3]SK&F 110679 was adsorbed on a hydrophilic microporous membrane, which was positioned on a support in the device and sealed in place. A silver/silver chloride electrode system was used for iontophoresis and a potentialof 4.5 V (rectangular pulse, 40 kHz, 30% duty cycle) was applied using an Advance depolarizing pulse iontophoresis system (ADIS-4030). Current-dependent appearance of [H-3]SK&F 110679 equivalents in blood, bile and urine did not depend on membrane loading between 1.8 and 8 mg adsorbed on the membrane. Blood levels of [H-3]SK&F 110679 equivalents persisted for at least 2 h after the current was turned off, indicativeof depot formation in the skin. Fractions of bile and urine were analyzed by reversed-phase high-performance liquid chromatography (HPLC). The radiochemical profiles were dominated by a single species, coeluting with intact [H-3]SK&F 110679. A flux of at least 0.8-1.2 ug/h per cm(2) was achieved, indicating that, with appropriate optimization of the patch device, therapeutic levels of SK&F 110679 in man may be attainable by transdermal iontophoresis. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 05:46:31