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Titolo:
THE INFLUENZA-VIRUS NEP (NS2 PROTEIN) MEDIATES THE NUCLEAR EXPORT OF VIRAL RIBONUCLEOPROTEINS
Autore:
ONEILL RE; TALON J; PALESE P;
Indirizzi:
CUNY MT SINAI SCH MED,DEPT MICROBIOL,1 GUSTAVE L LEVY PL NEW YORK NY 10029 CUNY MT SINAI SCH MED,DEPT MICROBIOL NEW YORK NY 10029
Titolo Testata:
EMBO journal
fascicolo: 1, volume: 17, anno: 1998,
pagine: 288 - 296
SICI:
0261-4189(1998)17:1<288:TIN(PM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRE-MESSENGER-RNA; REV ACTIVATION DOMAIN; TYPE-1 REV; NUCLEOCYTOPLASMIC TRANSPORT; SIGNAL; IDENTIFICATION; EXPRESSION; PATHWAY; IMPORT; TRANSACTIVATOR;
Keywords:
HIV; INFLUENZA VIRUS NEP(NS2); NUCLEOCYTOPLASMIC TRANSPORT; RIBONUCLEOPROTEIN; RNA EXPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
R.E. Oneill et al., "THE INFLUENZA-VIRUS NEP (NS2 PROTEIN) MEDIATES THE NUCLEAR EXPORT OF VIRAL RIBONUCLEOPROTEINS", EMBO journal, 17(1), 1998, pp. 288-296

Abstract

Nuclear import and export of viral nucleic acids is crucial for the replication cycle of many viruses, and elucidation of the mechanism of these steps may provide a paradigm for understanding general biological processes, Influenza virus replicates its RNA genome in the nucleus of infected cells, The influenza virus NS2 protein, which had no previously assigned function, was shown to mediate the nuclear export of,virion RNAs by acting as an adaptor between viral ribonucleoprotein complexes and the nuclear export machinery of the cell, A functional domain on the NS2 with characteristics of a nuclear export signal was mapped: it interacts with cellular nucleoporins, can functionally replace the effector domain of the human immuno-deficiency virus type 1 (HIV-1)Rev protein and mediates rapid nuclear export when cross-linked to a reporter protein, Microinjection of anti-NS2 antibodies into infected cells inhibited nuclear export of viral ribonucleoproteins, suggestingthat the Rev-like NS2 mediates this process, Therefore, we have renamed this Rev-like factor the influenza virus nuclear export protein or NEP, We propose a model by which NEP acts as a protein adaptor molecule bridging viral ribonucleoproteins and the nuclear pore complex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 11:58:39