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Titolo:
RAS TRANSFORMATION IS ASSOCIATED WITH DECREASED EXPRESSION OF THE BRMSNF2-ALPHA ATPASE FROM THE MAMMALIAN SWI-SNF COMPLEX/
Autore:
MUCHARDT C; BOURACHOT B; REYES JC; YANIV M;
Indirizzi:
INST PASTEUR,DEPT BIOTECHNOL,INST PASTEUR,URA 1644 CNRS,UNITE VIRUS ONCOGENES,25 RUE DR ROUX F-75724 PARIS 15 FRANCE INST PASTEUR,DEPT BIOTECHNOL,INST PASTEUR,URA 1644 CNRS,UNITE VIRUS ONCOGENES F-75724 PARIS 15 FRANCE
Titolo Testata:
EMBO journal
fascicolo: 1, volume: 17, anno: 1998,
pagine: 223 - 231
SICI:
0261-4189(1998)17:1<223:RTIAWD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOBLASTOMA PROTEIN; TRANSCRIPTIONAL ACTIVATORS; GLUCOCORTICOID RECEPTOR; DROSOPHILA-BRAHMA; TRANSGENIC MICE; HUMAN HOMOLOG; FAMILY; CELLS; GENE; BRG1;
Keywords:
BRAHMA; CELL CYCLE; CHROMATIN; TRANSCRIPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
C. Muchardt et al., "RAS TRANSFORMATION IS ASSOCIATED WITH DECREASED EXPRESSION OF THE BRMSNF2-ALPHA ATPASE FROM THE MAMMALIAN SWI-SNF COMPLEX/", EMBO journal, 17(1), 1998, pp. 223-231

Abstract

The brm and BRG-1 proteins are mutually exclusive subunits of the mammalian SWI-SNF complex. Within this complex, they provide the ATPase activity necessary for transcriptional regulation by nucleosome disruption. Both proteins were recently found to interact with the p105Rb tumor suppressor gene product, suggesting a role for the mammalian SWI-SNF complex in the control of cell growth. We show here that the expression of brm, but not BRG-1, is negatively regulated by mitogenic stimulation, and that growth arrest of mouse fibroblasts leads to increased accumulation of the brm protein, The expression of this protein is also down-regulated upon transformation by the ras oncogene. Re-introduction of brm into ras transformed cells leads to partial reversion of the transformed phenotype by a mechanism that depends on the ATPase domain of the protein. Our data suggest that increased levels of brm protein favour the withdrawal of the cell from the cycle whereas decreased expression of the brm gene may facilitate cellular transformation by various oncogenes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 09:10:03