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Titolo:
GIANT RENIN SECRETORY GRANULES IN BEIGE MOUSE RENAL AFFERENT ARTERIOLES
Autore:
JENSEN BL; RASCH R; NYENGAARD JR; SKOTT O;
Indirizzi:
ODENSE UNIV,DEPT PHYSIOL,WINSLOWPK 19 DK-5000 ODENSE DENMARK ODENSE UNIV,DEPT PHYSIOL DK-5000 ODENSE DENMARK AARHUS UNIV,DEPT CELL BIOL AARHUS DENMARK AARHUS UNIV,STEREOL RES LAB DK-8000 AARHUS DENMARK
Titolo Testata:
Cell and tissue research
fascicolo: 2, volume: 288, anno: 1997,
pagine: 399 - 406
SICI:
0302-766X(1997)288:2<399:GRSGIB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHEDIAK-HIGASHI-SYNDROME; MAST-CELLS; DE-GRANULATION; EXOCYTOSIS; MICE; RELEASE; DEFECT; MATRIX; RATS;
Keywords:
KIDNEY; RENIN; SECRETORY GRANULES; AFFERENT ARTERIOLES; IMMUNOHISTOCHEMISTRY; MOUSE, MUTANT BEIGE (C57BL/6 BG); MOUSE (NMRI);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
B.L. Jensen et al., "GIANT RENIN SECRETORY GRANULES IN BEIGE MOUSE RENAL AFFERENT ARTERIOLES", Cell and tissue research, 288(2), 1997, pp. 399-406

Abstract

The mutant beige mouse (C57BL/6 bg) has a disease characterised by abnormally enlarged cytoplasmic granules in a variety of cells. With thepurpose of establishing a suitable cellular model for studying renin secretion, the present study was undertaken to compare renin granule morphology in beige mice with that of control (NMRI) mice. Immunohistochemistry with an antibody specific for renin revealed intense stainingof the juxtaglomerular part of the afferent arterioles in both strains of mice. Plasma renin concentrations were higher in the controls than in the beige mice (4.4+/-0.6 vs 2.5+/-0.3 mGoldblatt units/ml). The total volume of renin granules per afferent arteriole was similar in the two mice strains (1114 mu m(3) in the controls and 1507 mu m(3) in the beige mice). The total number of renin granules per arteriole as assessed by stereological techniques was about 1900 in controls (average granular volume 0.681 mu m(3)), whereas 1-2 large granules were present per cell in beige mice. The volume of afferent arteriole that contained secretory granules was lower in the beige mice. We conclude thatthe beige mouse synthesizes, stores and releases active renin. Renin secretory granules in beige mice are grossly enlarged with 1-2 granules per juxtaglomerular cell. Compared with control mice, a similar amount of total renin granule volume per afferent arteriole is contained in a smaller part of beige mouse afferent arteriole. Granular cells from beige mice could therefore be a valuable tool in the study of renin release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:37:00