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Titolo:
CORONARY FLOW RESERVE IS REDUCED IN YOUNG MEN WITH IDDM
Autore:
PITKANEN OP; NUUTILA P; RAITAKARI OT; RONNEMAA T; KOSKINEN PJ; IIDA H; LEHTIMAKI TJ; LAINE HK; TAKALA T; VIIKARI JSA; KNUUTI J;
Indirizzi:
UNIV TURKU,CENT HOSP,DEPT MED,KIINAMYLLYNKATU 4-8 FIN-20520 TURKU FINLAND UNIV TURKU,DEPT MATH SF-20500 TURKU FINLAND UNIV TURKU,DEPT CLIN PHYSIOL SF-20500 TURKU FINLAND UNIV TURKU,DEPT CLIN CHEM SF-20500 TURKU FINLAND UNIV TURKU,TURKU PET CTR SF-20500 TURKU FINLAND TAMPERE UNIV HOSP,DEPT CLIN CHEM FIN-33521 TAMPERE FINLAND UNIV TAMPERE,SCH MED,DEPT BIOCHEM MED TAMPERE FINLAND RES CTR BRAIN & BLOOD VESSELS AKITA JAPAN
Titolo Testata:
Diabetes
fascicolo: 2, volume: 47, anno: 1998,
pagine: 248 - 254
SICI:
0012-1797(1998)47:2<248:CFRIRI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; MYOCARDIAL BLOOD-FLOW; DEPENDENT DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE; NONINVASIVE QUANTIFICATION; ARTERY DISEASE; HEART-DISEASE; N-13 AMMONIA; RISK-FACTORS; INSULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
O.P. Pitkanen et al., "CORONARY FLOW RESERVE IS REDUCED IN YOUNG MEN WITH IDDM", Diabetes, 47(2), 1998, pp. 248-254

Abstract

Disturbances of coronary circulation have been reported in diabetic patients with microvascular complications hut without obstructive coronary atherosclerosis. The aim of the present study was to investigate coronary flow reserve in young adult patients with IDDM but without microalbuminuria and diabetic autonomic neuropathy. Coronary flow reservewas determined in 12 nonsmoking male patients with IDDM (age 30.0 +/-6.6 years) and 12 healthy matched volunteers, Groups were similar with respect to blood pressure and serum lipid concentrations, and no subject had a positive family history of coronary heart disease. The patients with IDDM had normal exercise echocardiography and autonomic nervous function tests, Five patients had minimal background retinopathy, and none had microalbuminuria. Positron emission tomography and [O-15]H(2)0 were used to measure myocardial blood Plow at rest and after dipyridamole administration, The studies were performed during euglycemichyperinsulinemia (serum insulin similar to 70 mU/l),The baseline myocardial blood flow was similar in patients with IDDM and in control subjects (0.84 +/- 0.18 vs, 0.88 +/- 0.25 ml . g(-1). min(-1), NS). The myocardial blood flow during hyperemia was 29% lower in patients with IDDM (3.17 +/- 1.57) compared with the control subjects (4.45 +/- 1.37 ml . g(-1). min(-1), P < 0.05). Consequently, coronary now reserve (the ratio of flow during hyperemia and at rest) was lower in diabetic patients than in control subjects (3.76 +/- 1.69 vs. 5.31 +/- 1.86, P < 0.05) and the total coronary resistance during hyperemia was higher indiabetic patients (53.7 +/- 31.5) compared with the control subjects (31.4 +/- 11.6 mmHg . min . g . ml(-1), P < 0.05), The coronary flow reserve was similar in diabetic patients with and without mild background retinopathy No association was found between the coronary flow reserve and serum lipid or HbA(1c) values in either group, Coronary flow reserve is impaired in yelling adult males with IDDM and no or minimal microvascular complications and without any evidence of coronary heartdisease, This abnormality cannot be! explained by standard coronary heart disease risk factors, The results imply early impairment of coronary vascular reactivity in IDDM patients, which may represent an earlyprecursor of future coronary heart disease or may contribute to the pathogenesis of diabetic cardiomyopathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 19:32:52