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Titolo:
[H-3] IMIPRAMINE BINDING IN BRAIN SAMPLES FROM DEPRESSED SUICIDES ANDCONTROLS - 5-HT UPTAKE SITES COMPARED WITH SITES DEFINED BY DESMETHYLIMIPRAMINE
Autore:
LAWRENCE KM; KANAGASUNDARAM M; LOWTHER S; KATONA CLE; CROMPTON MR; HORTON RW;
Indirizzi:
ST GEORGE HOSP,SCH MED,DEPT PHARMACOL & CLIN PHARMACOL LONDON SW17 0RE ENGLAND ST GEORGE HOSP,SCH MED,DEPT PHARMACOL & CLIN PHARMACOL LONDON SW17 0RE ENGLAND UNIV COLL LONDON,SCH MED,DEPT PSYCHIAT LONDON W1N 8AA ENGLAND ST GEORGE HOSP,SCH MED,DEPT FORENS MED LONDON SW17 0RE ENGLAND
Titolo Testata:
Journal of affective disorders
fascicolo: 1-3, volume: 47, anno: 1998,
pagine: 105 - 112
SICI:
0165-0327(1998)47:1-3<105:[IBIBS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN UPTAKE SITES; PAROXETINE BINDING; )H-3>IMIPRAMINE BINDING; RAT-BRAIN; MONOAMINE METABOLITES; HUMAN-PLATELETS; FRONTAL-CORTEX; POST-MORTEM; VICTIMS; RECEPTORS;
Keywords:
SUICIDE; DEPRESSION; [H-3]IMIPRAMINE BINDING SITES; POSTMORTEM BRAIN TISSUE; ANTIDEPRESSANT DRUGS; FRONTAL CORTEX; PUTAMEN; SUBSTANTIA NIGRA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
K.M. Lawrence et al., "[H-3] IMIPRAMINE BINDING IN BRAIN SAMPLES FROM DEPRESSED SUICIDES ANDCONTROLS - 5-HT UPTAKE SITES COMPARED WITH SITES DEFINED BY DESMETHYLIMIPRAMINE", Journal of affective disorders, 47(1-3), 1998, pp. 105-112

Abstract

Using desmethylimipramine (DMI) defined and Na+ dependent [H-3]imipramine binding, we have examined both 5-HT uptake sites and sites unrelated to 5-HT uptake, in frontal cortex, putamen and substantia nigra ofsuicides with a firm retrospective diagnosis of depression and matched controls. No differences were seen between antidepressant-free suicides and controls, although [H-3]imipramine binding sites were significantly lower in putamen of the subgroup of non-violent suicides. The number of DMI defined [H-3]imipramine binding sites was also significantly lower in putamen of antidepressant-treated suicides. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:00:19