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Titolo:
INHIBITION OF GROWTH AND INDUCTION OF DIFFERENTIATION OF GLIOMA CELL-LINES BY ONCOSTATIN-M (OSM)
Autore:
HALFTER H; LOTFI R; WESTERMANN R; YOUNG P; RINGELSTEIN EB; STOGBAUER FT;
Indirizzi:
UNIV MUNSTER,NEUROL CLIN,ALBERT SCHWEITZER STR 33 D-48129 MUNSTER GERMANY UNIV MARBURG,INST ANAT CELL BIOL D-35037 MARBURG GERMANY
Titolo Testata:
Growth factors
fascicolo: 2, volume: 15, anno: 1998,
pagine: 135 - 147
SICI:
0897-7194(1998)15:2<135:IOGAIO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-RECEPTOR; SIGNAL TRANSDUCER; BRAIN-TUMORS; EXPRESSION; GP130; CLONING; GENE; AMPLIFICATION; PHENYLACETATE; PROLIFERATION;
Keywords:
GLIOMA CELLS; DIFFERENTIATION; GROWTH INHIBITION; ONCOSTATIN M; NEUROPOIETIC CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
H. Halfter et al., "INHIBITION OF GROWTH AND INDUCTION OF DIFFERENTIATION OF GLIOMA CELL-LINES BY ONCOSTATIN-M (OSM)", Growth factors, 15(2), 1998, pp. 135-147

Abstract

The neuropoietic cytokines of the interleukin-6 family are a group ofstructurally and functionally related polypeptides. We studied the effect of the multifunctional neuropoietic cytokines, including oncostatin M (OSM), leukemia inhibitory factor (LIF) and interleukin-6 (IL-6),on anaplastic glioma cell lines. Growth and morphology of the glioma cell lines were affected differently. While IL-6 and LIF exerted no oronly small minor morphological changes and growth retardation, OSM induced a marked change in morphology and a strong suppression of growth. OSM treated cells were characterized by enlargement and the formation of multiple, thin processes thus resembling mature cultured astrocytes. The growth inhibitory effects were dose dependent with a maximum exerted by addition of 50 ng/ml OSM. The inhibition of DNA synthesis byOSM could be abolished by antibodies blocking either the activity of OSM or the OSM-receptor component, gp130.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 00:19:23