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Titolo:
LIVER SLICES IN IN-VITRO PHARMACOTOXICOLOGY WITH SPECIAL REFERENCE TOTHE USE OF HUMAN LIVER-TISSUE
Autore:
OLINGA P; MEIJER DKF; SLOOFF MJH; GROOTHUIS GMM;
Indirizzi:
UNIV GRONINGEN,CTR PHARM,DEPT PHARMACOKINET & DRUG DELIVERY,GRONINGENINST DRUG STUDIES NL-9713 AV GRONINGEN NETHERLANDS UNIV GRONINGEN HOSP,DEPT SURG,DIV HEPATOBILIARY SURG & LIVER TRANSPLANTAT NL-9713 EZ GRONINGEN NETHERLANDS
Titolo Testata:
Toxicology in vitro
fascicolo: 1, volume: 12, anno: 1998,
pagine: 77 -
SICI:
0887-2333(1998)12:1<77:LSIIPW>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRECISION-CUT LIVER; ISOLATED HUMAN HEPATOCYTES; ADULT HUMAN HEPATOCYTES; CULTURED HUMAN HEPATOCYTES; OF-WISCONSIN SOLUTION; DYNAMIC ORGAN-CULTURE; PERFUSED RAT-LIVER; LONG-TERM CULTURE; DRUG-METABOLISM; IN-VITRO;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
197
Recensione:
Indirizzi per estratti:
Citazione:
P. Olinga et al., "LIVER SLICES IN IN-VITRO PHARMACOTOXICOLOGY WITH SPECIAL REFERENCE TOTHE USE OF HUMAN LIVER-TISSUE", Toxicology in vitro, 12(1), 1998, pp. 77

Abstract

In the early years of research in in vitro pharmacotoxicology liver slices have been used. After a decline in the application of slices in favour of the use of isolated hepatocytes and the isolated perfused liver preparation, the development of the Krumdieck slicer in the 1980s led to a 'comeback' of the technique. This review will focus on the use of human liver, with special reference to the comparison of slices with isolated hepatocytes in in vitro pharmacotoxicology. In addition, an overview on the predictive value of these in vitro systems for drugdisposition and toxicity in vivo will be given. Preservation techniques for liver slices and hepatocytes will also be discussed. These techniques ensure an efficient utilization of the scarce human material. For long-term storage of liver slices and hepatocytes, cryopreservationseems most promising. However, cryopreservation is still in its infancy, and reports mainly deal with drug metabolism studies after cryopreservation. Drug toxicity, metabolism and transport data determined in slices and isolated hepatocytes, from both human and animal liver showed good correlation with the corresponding parameters measured in vivo. Therefore, the results obtained in such studies may give rise to more in-depth research on the mechanisms of pharmactoxicology in the human liver. (C) 1998 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:11:38