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Titolo:
SHORT-TERM HEMODYNAMIC VARIABILITY IN THE CONSCIOUS AREFLEXIC RAT
Autore:
LETIENNE R; BARRES C; CERUTTI C; JULIEN C;
Indirizzi:
FAC PHARM LYON,CNRS,DEPT PHYSIOL & PHARMACOL CLIN,ESA 5014 F-69373 LYON 08 FRANCE FAC PHARM LYON,CNRS,DEPT PHYSIOL & PHARMACOL CLIN,ESA 5014 F-69373 LYON 08 FRANCE
Titolo Testata:
Journal of physiology
fascicolo: 1, volume: 506, anno: 1998,
pagine: 263 - 274
SICI:
0022-3751(1998)506:1<263:SHVITC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL-PRESSURE LABILITY; BLOOD-PRESSURE; PERIPHERAL RESISTANCE; SINOAORTIC DEAFFERENTATION; HEMODYNAMIC ANALYSIS; CIRCULATION; DENERVATION; RESPONSES; DOGS; TONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R. Letienne et al., "SHORT-TERM HEMODYNAMIC VARIABILITY IN THE CONSCIOUS AREFLEXIC RAT", Journal of physiology, 506(1), 1998, pp. 263-274

Abstract

1. Simultaneous measurements of arterial pressure and cardiac output (n = 8), mesenteric blood flow (n = 7) or hindquarters (n = 8) blood flow were performed during 1 h periods in conscious rats, before and after acute pharmacological blockade of the autonomic, renin-angiotensinand vasopressin systems. In the latter condition (areflexic state), arterial pressure was maintained with a continuous infusion of noradrenaline. 2. In the areflexic state, spontaneous fluctuations in arterialpressure were markedly exaggerated, especially depressor episodes. Atthe onset of these falls in arterial pressure, there was an abrupt and transient decrease in stroke volume and cardiac output. Systemic vasodilatation then developed while cardiac output returned to normal. Regional vasodilatations were also delayed from the onset of the falls in arterial pressure and were usually large enough to maintain blood flow. 3. Both time and frequency domain analyses confirmed that changes in systemic and regional vascular conductances lagged by about 1 s behind arterial pressure changes. 4. These results indicate that, in the absence of neurohumoral influences, autoregulatory-like mechanisms become dominant in the control of systemic and regional circulations and contribute to exaggeration of the spontaneous short-term variability of arterial pressure.

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Documento generato il 24/11/20 alle ore 14:43:01