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Titolo:
INVESTIGATION OF THE EFFECTS OF PLATELET-ACTIVATING-FACTOR (PAF) ON ION-TRANSPORT AND PROSTAGLANDIN SYNTHESIS IN HUMAN COLONIC MUCOSA IN-VITRO
Autore:
BORMAN RA; JEWELL R; HILLIER K;
Indirizzi:
UNIV SOUTHAMPTON,SCH MED,CLIN PHARMACOL GRP,BIOMED SCI BLDG,BASSETT CRESCENT E SOUTHAMPTON SO16 7PX HANTS ENGLAND
Titolo Testata:
British Journal of Pharmacology
fascicolo: 2, volume: 123, anno: 1998,
pagine: 231 - 236
SICI:
0007-1188(1998)123:2<231:IOTEOP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; ELECTROLYTE TRANSPORT; ULCERATIVE-COLITIS; ENDOTOXIC-SHOCK; RAT JEJUNUM; FATTY-ACIDS; INVOLVEMENT; SECRETION; CELLS; TOXIN;
Keywords:
PLATELET-ACTIVATING FACTOR (PAF); HUMAN COLON; ION TRANSPORT; PROSTAGLANDIN SYNTHESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Borman et al., "INVESTIGATION OF THE EFFECTS OF PLATELET-ACTIVATING-FACTOR (PAF) ON ION-TRANSPORT AND PROSTAGLANDIN SYNTHESIS IN HUMAN COLONIC MUCOSA IN-VITRO", British Journal of Pharmacology, 123(2), 1998, pp. 231-236

Abstract

1 We have investigated the effects of platelet-activating factor (PAF), an endogenous mediator of inflammation, on ion transport and prostaglandin synthesis in the human isolated colon. 2 Application of PAF tothe serosal surface of human colonic mucosa induced a marked, concentration-dependent increase in ion transport. Mucosal application was without effect. 3 The secretory response to PAF was significantly inhibited by prior application of a specific PAF receptor antagonist WEB 2170, indicating that the response is dependent on PAF receptor activation. 4 The response to PAF was attenuated by prior application of indomethacin or piroxicam, implicating products of the cyclo-oxygenase pathway in the response.5 The response to PAF was attenuated by the loop diuretic bumetanide, indicating an involvement of chloride ion secretionin the response. 6 Addition of PAF to the serosal surface induced a significant increase in serosal prostaglandin E-2 (PGE(2)), but not 6-oxo-PGF(1 alpha) release. There was no effect on mucosal application ofPAF. 7 In summary, we have shown that PAF is a potent secretagogue inisolated preparations of human colon and that the response is dependent on a specific PAF receptor, cyclo-oxygenase products and bumetanide-sensitive chloride ion transport.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:16:46