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Titolo:
BETA-CHEMOKINE RECEPTOR CCR5 SIGNALS VIA THE NOVEL TYROSINE KINASE RAFTK
Autore:
GANJU RK; DUTT P; WU LJ; NEWMAN W; AVRAHAM H; AVRAHAM S; GROOPMAN JE;
Indirizzi:
HARVARD UNIV,SCH MED,BETH ISRAEL MED CTR,HARVARD INST MED,DIV EXPT MED,4 BLACKFAN CIRCLE BOSTON MA 02115 HARVARD UNIV,SCH MED,BETH ISRAEL MED CTR,HARVARD INST MED,DIV EXPT MED BOSTON MA 02115 HARVARD UNIV,SCH MED,BETH ISRAEL MED CTR,DIV HEMATOL ONCOL BOSTON MA 02115 LEUKOSITE INC CAMBRIDGE MA 00000
Titolo Testata:
Blood
fascicolo: 3, volume: 91, anno: 1998,
pagine: 791 - 797
SICI:
0006-4971(1998)91:3<791:BRCSVT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTORS; FOCAL ADHESION KINASE; MOLECULAR-CLONING; HUMAN NEUTROPHILS; KAPOSIS-SARCOMA; T-CELLS; C-JUN; ACTIVATION; PATHWAY; RANTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
R.K. Ganju et al., "BETA-CHEMOKINE RECEPTOR CCR5 SIGNALS VIA THE NOVEL TYROSINE KINASE RAFTK", Blood, 91(3), 1998, pp. 791-797

Abstract

Chemokine receptors are coupled to G-proteins and their activation results in prominent changes in cell migration and growth. The downstream signaling pathways that mediate these effects of chemokines are largely uncharacterized. Macrophage inflammatory protein 1 beta (MIP 1 beta) binding to its cognate receptor CCR5 resulted in activation of the related adhesion focal tyrosine kinase (RAFTK), with subsequent activation of the cytoskeletal protein paxillin and the downstream transcriptional activators, c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) and p38 mitogen-activated protein (MAP) kinase. Inhibition of RAFTK by a dominant-negative kinase mutant markedly attenuated JNK/SAPK activity. Thus, RAFTK appears to provide a functional ''bridge'' for the transmission of CCR5 receptor signaling to the cytoskeleton and nucleus, primary sites of chemotaxis and growth regulation. (C) 1998 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:38:09