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Titolo:
DIPEPTIDASE INHIBITOR AND EPITHELIAL REMOVAL POTENTIATE LEUKOTRIENE D-4-INDUCED HUMAN TRACHEAL SMOOTH-MUSCLE CONTRACTION
Autore:
YAMAYA M; SEKIZAWA K; TERAJIMA M; OKINAGA S; OHRUI T; SASAKI H;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT GERIATR MED,AOBA KU,SEIRYO MACHI 1-1 SENDAI MIYAGI 980 JAPAN TOHOKU UNIV,SCH MED,DEPT GERIATR MED,AOBA KU SENDAI MIYAGI 980 JAPAN
Titolo Testata:
Respiration physiology
fascicolo: 1, volume: 111, anno: 1998,
pagine: 101 - 109
SICI:
0034-5687(1998)111:1<101:DIAERP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN RENAL DIPEPTIDASE; GUINEA-PIG TRACHEA; HUMAN MICROSOMAL DIPEPTIDASE; SLOW REACTING SUBSTANCES; LIQUID-CHROMATOGRAPHY; DEGRADING ENZYMES; METABOLISM; RELEASE; ANAPHYLAXIS; HISTAMINE;
Keywords:
AIRWAYS, SMOOTH MUSCLE, CONTRACTION; EPITHELIUM, BRONCHIAL, SMOOTH MUSCLE CONTRACTION; MAMMALS, HUMANS; MEDIATORS, LEUKOTRIENE D-4; PHARMACOLOGICAL AGENTS, DIPEPTIDASE INHIBITOR; SMOOTH MUSCLE, CONTRACTION, EPITHELIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M. Yamaya et al., "DIPEPTIDASE INHIBITOR AND EPITHELIAL REMOVAL POTENTIATE LEUKOTRIENE D-4-INDUCED HUMAN TRACHEAL SMOOTH-MUSCLE CONTRACTION", Respiration physiology, 111(1), 1998, pp. 101-109

Abstract

We investigated the role of epithelium in smooth muscle contraction induced by leukotriene D-4 (LTD4) in isolated human trachea. The contractile response to LTD4 was potentiated by an inhibitor of dipeptidasesL-cysteine and by removal of the epithelium. Both L-cysteine (3 x 10(-3) M) and removal of the epithelium shifted the concentration-response curves to LTD4, to lower concentrations by 0.7 and 0.6 log units, respectively. Incubation of cultured or isolated human tracheal epithelial cells with LTD4 resulted in the formation of LTE,, which was completely blocked by pretreatment with L-cysteine (3 x 10(-3) M). The isolated and cultured human tracheal epithelial cells contained microsomal dipeptidase (MDP) activity. Immunohistochemical study indicated MDP protein was present in the epithelium and endothelial cells of submucosal microvessels in the human trachea. These results suggest that the epithelium modulates the contractile response to LTD4 in human trachea by dipeptidases degrading LTD4. (C) 1998 Elsevier Science B.V.

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Documento generato il 12/07/20 alle ore 06:01:51