Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
UPDATE - CLINICALLY SIGNIFICANT CYTOCHROME-P-450 DRUG-INTERACTIONS
Autore:
MICHALETS EL;
Indirizzi:
MISSION ST JOSEPHS HLTH SYST,DEPT PHARM,509 BILTMORE AVE ASHEVILLE NC28801 UNIV N CAROLINA,SCH PHARM COMMUNITY BASED PRACTICE ASHEVILLE NC 28804
Titolo Testata:
Pharmacotherapy
fascicolo: 1, volume: 18, anno: 1998,
pagine: 84 - 112
SICI:
0277-0008(1998)18:1<84:U-CSCD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADES-DE-POINTES; ALTERS TERFENADINE PHARMACOKINETICS; GRAPEFRUIT JUICE; KETOCONAZOLE INTERACTION; NEWER ANTIDEPRESSANTS; PLASMA-CONCENTRATIONS; WARFARIN-FLUCONAZOLE; CISAPRIDE TREATMENT; QT INTERVAL; METABOLISM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
142
Recensione:
Indirizzi per estratti:
Citazione:
E.L. Michalets, "UPDATE - CLINICALLY SIGNIFICANT CYTOCHROME-P-450 DRUG-INTERACTIONS", Pharmacotherapy, 18(1), 1998, pp. 84-112

Abstract

Recent technologies have resulted in an explosion of information concerning the cytochrome P-450 isoenzymes and increased awareness of life-threatening interactions with such commonly prescribed drugs as cisapride and some antihistamines. Knowledge of the substrates, inhibitors,and inducers of these enzymes assists in predicting clinically significant drug interactions. In addition to inhibition and induction, microsomal drug metabolism is affected by genetic polymorphisms, age, nutrition, hepatic disease, and endogenous chemicals. Of the more than 30 human isoenzymes identified to date, the major ones responsible for drug metabolism include CYP3A4, CYP2D6, CYP1A2, and the CYP2C subfamily.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:02:33