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Titolo:
CAN CEREBROVASCULAR REACTIVITY BE ASSESSED BY DYNAMIC SUSCEPTIBILITY CONTRAST-ENHANCED MRI
Autore:
BERTHEZENE Y; NIGHOGHOSSIAN N; MEYER R; DAMIEN J; CINOTTI L; ADELEINE P; TROUILLAS P; FROMENT JC;
Indirizzi:
NEUROL HOSP,CREATIS UMR CNRS 5515,DEPT RADIOL,59 BD PINEL F-69003 LYON FRANCE NEUROL HOSP,NEUROL CEREBROVASC DIS & ATAXIA RES CTR LYON FRANCE NEUROL HOSP,DEPT NUCL MED LYON FRANCE UFR ALEXIS CARREL,MED INFORMAT LAB LYON FRANCE
Titolo Testata:
Neuroradiology
fascicolo: 1, volume: 40, anno: 1998,
pagine: 1 - 5
SICI:
0028-3940(1998)40:1<1:CCRBAB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; TRANSCRANIAL DOPPLER; ARTERY OCCLUSION; ACETAZOLAMIDE; RESERVE; PERFUSION; DISEASE; VOLUME;
Keywords:
BRAIN, BLOOD FLOW; CEREBRAL BLOOD VOLUME; MAGNETIC RESONANCE IMAGING; ACETAZOLAMIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
Y. Berthezene et al., "CAN CEREBROVASCULAR REACTIVITY BE ASSESSED BY DYNAMIC SUSCEPTIBILITY CONTRAST-ENHANCED MRI", Neuroradiology, 40(1), 1998, pp. 1-5

Abstract

The acetazolamide (ACZ) test is performed to evaluate the decrease incerebral perfusion pressure (CPP) by investigation of vasomotor reactivity (VMR), Our aim was to study cerebral blood flow and blood volumechanges induced by the ACZ test in healthy control subjects using dynamic susceptibility contrast-enhanced gradient-echo MRI (DSC-MRI), A FLASH sequence was used to produce susceptibility-weighted images during an intravenous injection of 0.1 mmol/kg gadopentetate dimeglumine (Gd-DTPA). After the first dynamic study, 1g acetazolamide was given intravenously and 10 min later a second bolus of Gd-DTPA, was injected, Using the indicator-dilution theory, relative cerebral blood volume andrelative cerebral blood flow were estimated. In healthy subjects the ACZ test induced a significant increase in relative blood volume (from80.5 +/- 10.7 to 113.4 +/- 11.9) and relative blood flow (from 5.73 +/- 0.96 to 7.5 +/- 0.97), symmetrically in the cerebral hemispheres. This approach might be promising in the understanding of cerebral haemodynamics in patients with vascular disorders.

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Documento generato il 22/10/20 alle ore 03:04:45