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Titolo:
PROLACTIN RESPONSE TO NEMONAPRIDE, A NEW ANTIPSYCHOTIC DRUG, IN SCHIZOPHRENIC-PATIENTS
Autore:
OTANI K; KONDO T; YASUI N; SUZUKI A; FURUKORI H; KANEKO S; OHKUBO T; NAGASAKI T; SUGAWARA K; HAYASHI K;
Indirizzi:
HIROSAKI UNIV HOSP,DEPT NEUROPSYCHIAT HIROSAKI AOMORI 036 JAPAN HIROSAKI UNIV HOSP,DEPT NEUROPSYCHIAT HIROSAKI AOMORI 036 JAPAN HIROSAKI UNIV HOSP,DEPT PHARM HIROSAKI AOMORI 036 JAPAN GOSHOGAWARA CITY HOSP,DEPT PHARM GOSHOGAWARA JAPAN GUNMA UNIV,SCH HLTH SCI,DEPT ALLIED MED SCI MAEBASHI GUMMA 371 JAPAN
Titolo Testata:
Human psychopharmacology
fascicolo: 6, volume: 12, anno: 1997,
pagine: 591 - 594
SICI:
0885-6222(1997)12:6<591:PRTNAN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL-RESPONSE; SERUM PROLACTIN; YM-09151-2; HALOPERIDOL; ZOTEPINE; BINDING;
Keywords:
NEMONAPRIDE; PROLACTIN; D2 RECEPTOR; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
K. Otani et al., "PROLACTIN RESPONSE TO NEMONAPRIDE, A NEW ANTIPSYCHOTIC DRUG, IN SCHIZOPHRENIC-PATIENTS", Human psychopharmacology, 12(6), 1997, pp. 591-594

Abstract

The prolactin response to nemonapride, a new antipsychotic drug, was studied in 27 schizophrenic inpatients (12 males, 15 females). The daily dose of nemonapride was 18 mg/day, and the duration of treatment was 3 weeks. Plasma prolactin concentrations were measured by enzyme immunoassay. Nemonapride treatment significantly (p < 0.01) increased prolactin concentrations at each week in both genders. The Delta prolactin (the mean concentration during 3 weeks minus the pretreatment concentration) was significantly (p < 0.01) greater in females (mean +/- SD,81.6 +/- 57.8 ng/ml) than males (34.9 +/- 19.8 ng/ml). The present study thus shows that nemonapride treatment markedly increases prolactinconcentrations in schizophrenic patients, with greater responses in females than males, suggesting a strong D2 receptor blockade property of the drug. (C) 1997 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:55:39