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Titolo:
A COMPARISON OF THE EFFECTS OF FENTANYL AND PROPOFOL ON LEFT-VENTRICULAR CONTRACTILITY DURING MYOCARDIAL STUNNING
Autore:
ROSS S; MUNOZ H; PIRIOU V; RYDER WA; FOEX P;
Indirizzi:
UNIV OXFORD,RADCLIFFE INFIRM,NUFFIELD DEPT ANAESTHET,WOODSTOCK RD OXFORD OX2 6HE ENGLAND
Titolo Testata:
Acta anaesthesiologica Scandinavica
fascicolo: 1, volume: 42, anno: 1998,
pagine: 23 - 31
SICI:
0001-5172(1998)42:1<23:ACOTEO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONICALLY INSTRUMENTED DOGS; FREE-RADICAL GENERATION; ISOLATED RAT-HEART; OXYGEN-CONSUMPTION; SUPEROXIDE-DISMUTASE; FUNCTIONAL RECOVERY; ACTION-POTENTIALS; CARDIAC-SURGERY; ANESTHESIA; DYSFUNCTION;
Keywords:
ANESTHETICS, INTRAVENOUS, PROPOFOL; ANALGESICS, OPIOID, FENTANYL; HEART, CORONARY CIRCULATION, ISCHEMIA, OCCLUSION; HEART, STUNNED MYOCARDIUM, POSTISCHEMIC, REPERFUSION, DOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
S. Ross et al., "A COMPARISON OF THE EFFECTS OF FENTANYL AND PROPOFOL ON LEFT-VENTRICULAR CONTRACTILITY DURING MYOCARDIAL STUNNING", Acta anaesthesiologica Scandinavica, 42(1), 1998, pp. 23-31

Abstract

Background: The intravenous anaesthetic propofol has been shown to possess free radical scavenging activity and calcium channel blocking effects in a number of in vitro models. We decided to compare the effects of propofol with those of fentanyl on myocardial contractility during and after ischaemia to determine whether propofol could protect the heart and improve recovery of ventricular contractile function in open-chested dogs. Methods: Twenty adult beagles were acutely instrumented, under halothane anaesthesia, to measure ECG; aortic, left ventricular pressures; cardiac output; coronary flow; and segmental lengths in the regions perfused by the left anterior and left circumflex coronary arteries. After surgery and a stabilisation period halothane anaesthesia was terminated and fentanyl (100 mu g . kg(-1) bolus followed by 2 mu g . kg(-1) . min(-1) infusion; n=10) or propofol (5 mg . kg(-1) bolus followed by 0.3 mg . kg(-1) . min(-1) infusion; n=10) anaesthesia commenced. After a stabilisation period the LAD coronary artery was occluded for 10 min and then reperfused for 3 h. Measurements were taken throughout the protocol. Results: We found no significant difference in recovery of contractile function between propofol and fentanyl as assessed by normalised preload recruitable work area (50+/-10 vs 47+/-16%), normalised systolic shortening (36+/-12 vs 48+/-14%) and peak leftventricular dP/dt (1665+/-276 vs 1846+/-151 mmHg . s(-1)) at the end of reperfusion. Conclusion: We conclude that at the concentration usedin this study propofol shows no improvement in contractility during ''stunning'' when compared to fentanyl. (C) Acta Anaesthesiologica Scandinavica 42 (1998).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:49:05