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Titolo:
HYPOXIA REGULATES ENDOTHELIN-1 PRODUCTION BY THE INNER MEDULLARY COLLECTING DUCT
Autore:
MILLER RL; KOHAN DE;
Indirizzi:
VET AFFAIRS MED CTR,MED CARE CTR 111,DEPT MED,500 FOOTHILL BLVD SALT LAKE CITY UT 84148 VET AFFAIRS MED CTR,MED CARE CTR 111,DEPT MED SALT LAKE CITY UT 84148 VET AFFAIRS MED CTR,DEPT PHYSIOL SALT LAKE CITY UT 84148 UNIV UTAH,SCH MED SALT LAKE CITY UT 84112 UNIV UTAH,ECCLES PROGRAM HUMAN MOL BIOL & GENET SALT LAKE CITY UT 84112
Titolo Testata:
The Journal of laboratory and clinical medicine
fascicolo: 1, volume: 131, anno: 1998,
pagine: 45 - 48
SICI:
0022-2143(1998)131:1<45:HREPBT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOCONSTRICTOR PEPTIDE; RAT-KIDNEY; EXPRESSION; GROWTH; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Miller e D.E. Kohan, "HYPOXIA REGULATES ENDOTHELIN-1 PRODUCTION BY THE INNER MEDULLARY COLLECTING DUCT", The Journal of laboratory and clinical medicine, 131(1), 1998, pp. 45-48

Abstract

Renal endothelin-1 (ET-1) production is increased by hypoxia and has been implicated in ischemia-induced renal hypoperfusion. Because the inner medullary collecting duct (IMCD) is a major source of ET-1 in thekidney, and because ET-1-in the setting of ischemic renal failure-mayalter medullary perfusion, we sought to determine whether hypoxia modulated ET-1 production by IMCD cells, Primary cultures of rat IMCD cells were exposed to 21%, 3%, or 0% O-2. IMCD ET-1 secretion significantly increased after exposure of cultures to 3% O-2 (114.1% +/- 4.7% increase over control value) and 0% O-2 (171.7% +/- 7.9% increase), ET-1 mRNA levels, as determined by reverse transcription-polymerase chain reaction, also increased 2.5-fold after 24-hour exposure to 0% O-2, We speculate that a hypoxia-induced increase in IMCD ET-1 production plays a role in modulating renal medullary perfusion during ischemic renalfailure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:42:20