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Titolo:
THE ROLE OF GLUTAMATE IN PHYSICAL-DEPENDENCE ON OPIOIDS
Autore:
ZHU H; ROCKHOLD RW; HO IK;
Indirizzi:
UNIV MISSISSIPPI,MED CTR,DEPT PHARMACOL & TOXICOL,2500 N STATE ST JACKSON MS 39216 UNIV MISSISSIPPI,MED CTR,DEPT PHARMACOL & TOXICOL JACKSON MS 39216
Titolo Testata:
Japanese Journal of Pharmacology
fascicolo: 1, volume: 76, anno: 1998,
pagine: 1 - 14
SICI:
0021-5198(1998)76:1<1:TROGIP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-COERULEUS NEURONS; NALOXONE-PRECIPITATED WITHDRAWAL; EXCITATORY AMINO-ACIDS; LONG-TERM POTENTIATION; CENTRAL NERVOUS-SYSTEM; SPINAL-CORD NEURONS; KINASE-C ACTIVITY; MORPHINE-WITHDRAWAL; OPIATE WITHDRAWAL; RAT-BRAIN;
Keywords:
GLUTAMATE; PHYSICAL DEPENDENCE; WITHDRAWAL; LOCUS COERULEUS; N-METHYL-D-ASPARTATE RECEPTOR; MORPHINE; BUTORPHANOL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
150
Recensione:
Indirizzi per estratti:
Citazione:
H. Zhu et al., "THE ROLE OF GLUTAMATE IN PHYSICAL-DEPENDENCE ON OPIOIDS", Japanese Journal of Pharmacology, 76(1), 1998, pp. 1-14

Abstract

The present review will evaluate the interactions between kappa-opioid receptors and glutamate within the locus coeruleus (LC) during the development of opioid dependence and on expression of withdrawal from dependence on opioids. Hyperactivity of noradrenergic neurons in the LChas been proposed to play a critical role in the physiological and behavioral responses that comprise opioid withdrawal. Several studies indicate that the excitatory amino acid system, in particular, glutamateand its receptors, participate in both the withdrawal-associated increase in LC neuronal activity and the expression of opioid withdrawal behaviors. Most studies on opioid dependence have focused on the prototypical opioid morphine, which produces its physical dependence throughagonist actions at the mu-opioid receptor. Butorphanol (Stadol(R)), which exhibits a markedly different profile of opioid receptor activitythan does morphine, produces its physical dependence primarily through actions at the kappa-opioid receptor. Studies from our laboratories using a rodent model in which butorphanol administration induces dependence indicate further that the kappa-opioid receptor is an important regulator of glutamate release within the LC. Glutamate exerts actionswithin the LC that mediate expression of behavioral symptoms of butorphanol withdrawal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:34:29