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Titolo:
HISTOLOGIC EVALUATION OF PREVENTIVE MEASURES FOR SCALD INJURY ON THE PERITONEO-SEROSAL SURFACE DUE TO INTRAOPERATIVE HYPERTHERMIC CHEMOPERFUSION FOR PATIENTS WITH GASTRIC-CANCER AND PERITONEAL METASTASIS
Autore:
FUJIMOTO S; TAKAHASHI M; KOBAYASHI K; MUTOU T; TOYOSAWA T; IZAWA E; NUMAI T; KONDOH F; OHKUBO H;
Indirizzi:
SOCIAL INSURANCE FUNABASHI CENT HOSP,6-13-10 KAIJIN FUNABASHI CHIBA 273 JAPAN
Titolo Testata:
International journal of hyperthermia
fascicolo: 1, volume: 14, anno: 1998,
pagine: 75 - 83
SICI:
0265-6736(1998)14:1<75:HEOPMF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSION; CHEMOHYPERTHERMIA; RECURRENCE; CIMETIDINE; SURGERY; THERAPY;
Keywords:
PREVENTIVE MEASURES FOR SCALD INJURY; HYPERTHERMIC CHEMOPERFUSION; GASTRIC CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
S. Fujimoto et al., "HISTOLOGIC EVALUATION OF PREVENTIVE MEASURES FOR SCALD INJURY ON THE PERITONEO-SEROSAL SURFACE DUE TO INTRAOPERATIVE HYPERTHERMIC CHEMOPERFUSION FOR PATIENTS WITH GASTRIC-CANCER AND PERITONEAL METASTASIS", International journal of hyperthermia, 14(1), 1998, pp. 75-83

Abstract

To histologically assess the preventive efficacy of cimetidine against scald injury on the peritoneo-serosal surface during intraperitonealhyperthermic chemoperfusion (IHCP) for advanced gastric cancer, a randomized histologic study using cimetidine, a histamine H-2-receptor antagonist, was performed for 20 patients with advanced or recurrent gastric cancer and peritoneal metastasis. Cimetidine 50 mg/kg was administered intravenously to 10 patients just prior to the IHCP (cimetidine group), and the remaining 10 patients underwent the IHCP without cimetidine (control group). The background factors and IHCP treatments of these two groups were nearly the same. Although the antitumour efficacyof the IHCP was not histologically different between the two groups, the histological analysis revealed that the peritoneo-serosal surface in the cimetidine group was protected against scald injury, compared with the control group. This finding suggests that pre-IHCP cimetidine is of great benefit for protecting the peritoneo-serosal surface from scald injury due to IHCP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 05:07:36