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Titolo:
METADOXINE ACCELERATES FATTY LIVER RECOVERY IN ALCOHOLIC PATIENTS - RESULTS OF A RANDOMIZED DOUBLE-BLIND, PLACEBO-CONTROL TRIAL
Autore:
CABALLERIA J; PARES A; BRU C; MERCADER J; PLAZA AG; CABALLERIA L; CLEMENTE G; RODRIGO L; RODES J;
Indirizzi:
UNIV BARCELONA,HOSP CLIN & PROV,LIVER UNIT,VILLARROEL 170 BARCELONA 08036 SPAIN UNIV BARCELONA,HOSP CLIN & PROV,DEPT RADIOL BARCELONA 08036 SPAIN HOSP VIRGEN ARRIXACA,DEPT GASTROENTEROL MURCIA SPAIN HOSP RAMON Y CAJAL,DEPT GASTROENTEROL MADRID SPAIN HOSP GREGORIO MARANON,DEPT GASTROENTEROL MADRID SPAIN UNIV OVIEDO,HOSP CENT ASTURIAS E-33080 OVIEDO SPAIN
Titolo Testata:
Journal of hepatology
fascicolo: 1, volume: 28, anno: 1998,
pagine: 54 - 60
SICI:
0168-8278(1998)28:1<54:MAFLRI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PYRIDOXOL L,2-PYRROLIDON-5 CARBOXYLATE; LIPID-PEROXIDATION; DISEASE; RATS; ULTRASOUND; STEATOSIS; FIBROSIS; ULTRASONOGRAPHY; FIBROGENESIS; GLUTATHIONE;
Keywords:
ALCOHOLIC LIVER DISEASE; METADOXINE; STEATOSIS; ULTRASONOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
J. Caballeria et al., "METADOXINE ACCELERATES FATTY LIVER RECOVERY IN ALCOHOLIC PATIENTS - RESULTS OF A RANDOMIZED DOUBLE-BLIND, PLACEBO-CONTROL TRIAL", Journal of hepatology, 28(1), 1998, pp. 54-60

Abstract

Background/Aims: Our aim was to investigate the effectiveness of metadoxine (pyridoxol L, 2 pyrrolidone-5-carboxylate) in the treatment of alcoholic fatty liver, Methods: A double-blind randomized multicenter trial involving 136 chronic active alcoholic patients diagnosed with fatty liver by clinical, biochemical and ultrasonographic criteria was performed, Patients were treated with 1500 mg/day of metadoxine (n = 69) or placebo (n = 67) for 3 months, Patients were clinically and biochemically evaluated every month, Ultrasonography was performed before and after treatment, Results: At the end of the study there was a significant improvement in the liver function tests in both groups. However, the changes were more rapid and greater in patients treated with metadoxine, in whom significant changes in serum levels of bilirubin, aminotransferases and gammaglutamyl transpeptidase were already observedafter 1 month of treatment, and normalization of these parameters wasobserved at the end, After treatment, the percentage of patients withultrasonographic signs of steatosis was significantly lower in the metadoxine group (28% vs 70%, p<0.01) and the degree of steatosis was also lower in this group, Sixteen patients treated with metadoxine and 15 with placebo continued drinking, Alcohol intake was lower than initially, and similar in both groups, In the metadoxine group, the biochemical changes were similar in both the abstinent and the nonabstinent patients, In contrast, in the placebo group the improvement in the liver function tests was significantly higher in abstinents, Among patients who continued drinking, the prevalence (45% vs 92%, p<0.05) and the degree of steatosis were also significantly lower in patients treated with metadoxine. Conclusions: In patients with alcoholic fatty liver, metadoxine accelerates the normalization of liver function tests and the ultrasonographic changes, even in those who do not completely abstain from alcohol intake, Thus, metadoxine could be useful in the treatment of the early stages of alcoholic liver disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:27:08