Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PROTEIN-KINASE-B KINASES THAT MEDIATE PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT ACTIVATION OF PROTEIN-KINASE-B
Autore:
STEPHENS L; ANDERSON K; STOKOE D; ERDJUMENTBROMAGE H; PAINTER GF; HOLMES AB; GAFFNEY PRJ; REESE CB; MCCORMICK F; TEMPST P; COADWELL J; HAWKINS PT;
Indirizzi:
BABRAHAM INST,INOSITIDE LAB CAMBRIDGE CB2 4AT ENGLAND UNIV CALIF SAN FRANCISCO,CANC RES INST SAN FRANCISCO CA 94115 MEM SLOAN KETTERING CANC CTR,PROGRAM MOL BIOL NEW YORK NY 10021 UNIV CAMBRIDGE,DEPT CHEM CAMBRIDGE CB2 1EW ENGLAND UNIV LONDON KINGS COLL,DEPT CHEM LONDON WC2R 2LS ENGLAND
Titolo Testata:
Science
fascicolo: 5351, volume: 279, anno: 1998,
pagine: 710 - 714
SICI:
0036-8075(1998)279:5351<710:PKTMP3>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
3-KINASE; AKT; PHOSPHATIDYLINOSITOL(3,4,5)-TRISPHOSPHATE; EGF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
L. Stephens et al., "PROTEIN-KINASE-B KINASES THAT MEDIATE PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT ACTIVATION OF PROTEIN-KINASE-B", Science, 279(5351), 1998, pp. 710-714

Abstract

Protein kinase B (PKB) is activated in response to phosphoinositide 3-kinases and their lipid products phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P-3] and PtdIns(3,4)P-2 in the signaling pathways used by a wide variety of growth factors, antigens, and inflammatory stimuli. PKB is a direct target of these lipids, but this regulation is complex. The lipids can bind to the pleckstrin homologqus domain of PKB, causing its translocation to the membrane, and also enable upstream, Thr(308)-directed kinases to phosphorylate and activate PKB. Four isoforms of these PKB kinases were purified from sheep brain. They boundPtdIns(3,4,5)P-3 and associated with lipid vesicles containing ii. These kinases contain an NH2-terminal catalytic domain and a COOH-terminal pleckstrin homologous domain, and their heterologous expression augments receptor activation of PKB, which suggests they are the primary signal transducers that enable PtdIns(3,4,5)P-3 or PtdIns(3,4)P-2 to activate PKB and hence to control signaling pathways regulating cell survival, glucose uptake, and glycogen metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 19:33:05