Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LOSS OF CELL-ADHESION IN XENOPUS-LAEVIS EMBRYOS MEDIATED BY THE CYTOPLASMIC DOMAIN OF XLERK, AN ERYTHROPOIETIN-PRODUCING HEPATOCELLULAR LIGAND
Autore:
JONES TL; CHONG LD; KIM J; XU RH; KUNG HF; DAAR IO;
Indirizzi:
NCI,LAB LEUKOCYTE BIOL,FREDERICK INTRAMURAL RES SUPPORT PROGRAM,FREDERICK CANC RES & DEV CTR FREDERICK MD 21702 NCI,LAB LEUKOCYTE BIOL,FREDERICK INTRAMURAL RES SUPPORT PROGRAM,FREDERICK CANC RES & DEV CTR FREDERICK MD 21702 NCI,LAB BIOCHEM PHYSIOL,FREDERICK INTRAMURAL RES SUPPORT PROGRAM,FREDERICK CANC RES & DEV CTR FREDERICK MD 21702 NCI,SCI APPLICAT INT CORP,FREDERICK INTRAMURAL RES SUPPORT PROGRAM,FREDERICK CANC RES & DEV CTR FREDERICK MD 21702
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 2, volume: 95, anno: 1998,
pagine: 576 - 581
SICI:
0027-8424(1998)95:2<576:LOCIXE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASES; IN-VITRO; MESODERM INDUCTION; COMMISSURAL AXONS; EPH RECEPTORS; GROWTH-FACTOR; EXPRESSION; FAMILY; GUIDANCE; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Jones et al., "LOSS OF CELL-ADHESION IN XENOPUS-LAEVIS EMBRYOS MEDIATED BY THE CYTOPLASMIC DOMAIN OF XLERK, AN ERYTHROPOIETIN-PRODUCING HEPATOCELLULAR LIGAND", Proceedings of the National Academy of Sciences of the United Statesof America, 95(2), 1998, pp. 576-581

Abstract

The erythropoietin-producing hepatocellular (Eph) family of ligands and receptors has been implicated in the control of axon guidance and the segmental restriction of cells during embryonic development. In this report, we show that ectopic expression of XLerk, a Xenopus homologue of the murine Lerk-2 (ephrin-B1) transmembrane ligand, causes dissociation of Xenopus embryonic blastomeres by the mid-blastula transition. Moreover, a mutant that lacks the extracellular receptor binding domain can induce this phenotype. The carboxyl-terminal 19 amino acids ofthe cytoplasmic domain of XLerk are necessary but not sufficient to induce cellular dissociation. Basic fibroblast growth factor, but not activin, can rescue both the loss of cell adhesion and mesoderm induction in ectodermal explants expressing XLerk. Collectively, these results show that the cytoplasmic domain of XLerk has a signaling function that is important for cell adhesion, and fibroblast growth factor signaling modulates this function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:00:20