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Titolo:
DIRECT EVIDENCE FOR THE ROLE OF NEUROPEPTIDE-Y IN SYMPATHETIC-NERVE STIMULATION-INDUCED VASOCONSTRICTION
Autore:
HAN SP; YANG CL; CHEN XL; NAES L; COX BF; WESTFALL T;
Indirizzi:
ST LOUIS UNIV,SCH MED,DEPT PHARMACOL & PHYSIOL SCI,HLTH SCI CTR,1402 S GRAND BLVD ST LOUIS MO 63104
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 1, volume: 43, anno: 1998,
pagine: 290 - 294
SICI:
0363-6135(1998)43:1<290:DEFTRO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST BIBP-3226; NEUROEFFECTOR JUNCTION; RAT; NORADRENALINE; CAT; NPY;
Keywords:
BIBP-3226; NEUROPEPTIDE Y RELEASE; ADENOSINE 5'-TRIPHOSPHATE; MESENTERIC VASCULAR BED; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
S.P. Han et al., "DIRECT EVIDENCE FOR THE ROLE OF NEUROPEPTIDE-Y IN SYMPATHETIC-NERVE STIMULATION-INDUCED VASOCONSTRICTION", American journal of physiology. Heart and circulatory physiology, 43(1), 1998, pp. 290-294

Abstract

Neuropeptide Y (NPY) is a vasoconstrictor peptide and a cotransmitterwith norepinephrine (NE) in sympathetic nerve terminals and is thought to be involved in sympathetic nerve stimulation (SNS)-induced vasoconstriction. Using BIBP-3226, a Y-1 receptor selective antagonist, we examined this hypothesis in the isolated and perfused mesenteric vascular bed. SNS produced a frequency-dependent increase in perfusion pressure and concomitant overflow of NPY immunoreactivity in the perfusate.[Leu(31), Pro(34)]Npy potentiated NE-induced and ATP-induced vasoconstriction, indicating the presence and biological action of Y-1 receptors in this vascular bed. The potentiation effect of [Leu(31),Pro(34)]Npy of the increase in perfusion pressure by NE, ATP, or SNS was prevented by BIBP-3226. In addition, SNS-induced vasoconstriction at both high and low frequencies was significantly attenuated by BIBP-3226 at a concentration that completely blocked the [Leu(31),Pro(34)]Npy- induced potentiation of the NE- or ATP-induced vasoconstrictor effect. Theseresults suggest that similar to 30% of vasoconstriction produced by SNS depends on NPY in the mesenteric vascular bed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:11:07