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Titolo:
BEAT-TO-BEAT ESTIMATION OF WINDKESSEL MODEL PARAMETERS IN CONSCIOUS RATS
Autore:
MOLINO P; CERUTTI C; JULIEN C; CUISINAUD G; GUSTIN MP; PAULTRE C;
Indirizzi:
FAC PHARM LYON,DEPT PHYSIOL & CLIN PHARMACOL,CNRS,ESA 5014,8 AVE ROCKEFELLER F-69373 LYON 08 FRANCE FAC PHARM LYON,DEPT PHYSIOL & CLIN PHARMACOL,CNRS,ESA 5014 F-69373 LYON 08 FRANCE
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 1, volume: 43, anno: 1998,
pagine: 171 - 177
SICI:
0363-6135(1998)43:1<171:BEOWMP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC ARTERIAL COMPLIANCE; HYPERTENSIVE RATS; CAROTID-ARTERY; PERIPHERAL RESISTANCE; AORTIC COMPLIANCE; IN-VIVO; PRESSURE; DISTENSIBILITY;
Keywords:
EXPONENTIAL DECAY TIME; AORTIC BLOOD PRESSURE; CARDIAC OUTPUT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
P. Molino et al., "BEAT-TO-BEAT ESTIMATION OF WINDKESSEL MODEL PARAMETERS IN CONSCIOUS RATS", American journal of physiology. Heart and circulatory physiology, 43(1), 1998, pp. 171-177

Abstract

A windkessel model was applied on a beat-to-beat basis to evaluate the arterial mechanical characteristics in seven conscious rats. Ascending aortic arterial pressure (AP) and blood flow were recorded during steady-state in basal conditions, during infusions of isoprenaline, sodium nitroprusside, and phenylephrine, and after intravenous atenolol injection. For each cardiac cycle the exponential decay time constant (tau) was estimated from the aortic AP curve, peripheral resistances (R) were taken as the ratio of mean AP to cardiac output, and systemic arterial compliance (C) was calculated as tau/R. In all conditions, mean correlation coefficients of the exponential regression and similar to 70% of values in each rat were >0.99, demonstrating the model validity. In all conditions t and C exhibited a large spontaneous variability over time, and beat-to-beat correlations were high between tau and C(0.83 +/- 0.03). C was increased by sodium nitroprusside, decreased by isoprenaline, but not significantly decreased by phenylephrine [5.1 /- 0.2, 3.2 +/- 0.3, and 3.9 +/- 0.2 mu l/mmHg, respectively, vs. 4.2+/- 0.3 mu l/mmHg (baseline)]. In conclusion, the windkessel model enables tau and C to be reliably estimated in conscious rats during spontaneous and drug-induced hemodynamic variations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:09:12