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Titolo:
A SEPTIDE-SENSITIVE RECEPTOR IS NOT INVOLVED IN TACHYKININ-MEDIATED SECRETORY AND INOSITOL PHOSPHATE RESPONSES IN RAT PAROTID-GLAND - ARE SEVERAL TRANSDUCTION PATHWAYS INVOLVED AFTER THE STIMULATION OF THE NK1RECEPTOR
Autore:
HULEUX C; BERTHIER A; ROSSIGNOL B; DREUX C;
Indirizzi:
UNIV PARIS 11,CNRS ERS 571,BAT 430 F-91405 ORSAY FRANCE UNIV PARIS 11,CNRS ERS 571 F-91405 ORSAY FRANCE
Titolo Testata:
Journal of neurochemistry
fascicolo: 2, volume: 70, anno: 1998,
pagine: 858 - 864
SICI:
0022-3042(1998)70:2<858:ASRINI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-P RECEPTOR; SELECTIVE AGONISTS; URINARY-BLADDER; NEUROKININ RECEPTORS; PROTEIN SECRETION; EXOCYTOSIS; ANTAGONIST; RP-67580; SUBTYPES; SEQUENCE;
Keywords:
SUBSTANCE P; SUBSTANCE P(4-11); SEPTIDE; RP67580; PAROTID GLANDS; PROTEIN SECRETION; INOSITOL PHOSPHATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
C. Huleux et al., "A SEPTIDE-SENSITIVE RECEPTOR IS NOT INVOLVED IN TACHYKININ-MEDIATED SECRETORY AND INOSITOL PHOSPHATE RESPONSES IN RAT PAROTID-GLAND - ARE SEVERAL TRANSDUCTION PATHWAYS INVOLVED AFTER THE STIMULATION OF THE NK1RECEPTOR", Journal of neurochemistry, 70(2), 1998, pp. 858-864

Abstract

In the rat parotid gland, the neuropeptide substance P (SP), as well as SP(4-11), and septide elicited inositol phosphate production (EC50 values 0.44, 2, and 20 nM, respectively), No additivity of the maximalresponse to the three agonists was observed. SP, SP(4-11), and septide also stimulated protein secretion; for SP, two EC50 were determined (0.5 and 160 nM), whereas a single one could be determined for SP(4-11) and septide (EC50 values 15 and 20 nM, respectively). The selective tachykinin NK1 receptor antagonist RP67580 acted as a competitive inhibitor of both SP-and SP(4-11)-induced inositol phosphate production. its effect on septide-induced inositol phosphate production was noncompetitive, RP67580 is apparently as potent at antagonizing septide, SP, or SP(4-11) (in all cases K-B = 3 nM). These results show that in parotid gland, only NK1 receptors are activated by SP, SP(4-11), and septide. We also showed that the protein secretion stimulated by SP was inhibited competitively by RP67580, whereas the effect of RP67580 was noncompetitive on protein secretion when SP(4-11) or septide was used. Our data indicate that in rat parotid gland, the existence of a specific''septide-sensitive'' receptor can be ruled out and that only the NK1receptor is present and mediates cellular responses. Taken together, these results show that in this tissue the NK1 receptor would present at least two different binding sites that could be coupled to different transduction pathways and that would regulate protein secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 08:04:50