Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE SURFACE EPITHELIUM OF RECURRENT INFECTED PALATINE TONSILS IS RICHIN GAMMA-DELTA T-CELLS
Autore:
OLOFSSON K; HELLSTROM S; HAMMARSTROM ML;
Indirizzi:
UMEA UNIV,DEPT IMMUNOL S-90185 UMEA SWEDEN UMEA UNIV,DEPT IMMUNOL S-90185 UMEA SWEDEN UMEA UNIV HOSP,DEPT OTORHINOLARYNGOL S-90185 UMEA SWEDEN
Titolo Testata:
Clinical and experimental immunology
fascicolo: 1, volume: 111, anno: 1998,
pagine: 36 - 47
SICI:
0009-9104(1998)111:1<36:TSEORI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD8 ACCESSORY MOLECULE; INFLAMED HUMAN GINGIVA; HUMAN LYMPHOCYTES-T; INTRAEPITHELIAL LYMPHOCYTES; GERMINAL-CENTERS; STREPTOCOCCAL TONSILLITIS; CRYPT EPITHELIUM; IN-SITU; RECOGNITION; GAMMA/DELTA;
Keywords:
PALATINE TONSILS; INTRAEPITHELIAL LYMPHOCYTES; GAMMA-DELTA T CELLS; V-GENE; USAGE; IMMUNOMORPHOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
K. Olofsson et al., "THE SURFACE EPITHELIUM OF RECURRENT INFECTED PALATINE TONSILS IS RICHIN GAMMA-DELTA T-CELLS", Clinical and experimental immunology, 111(1), 1998, pp. 36-47

Abstract

Using a large panel of MoAbs in quantitative morphometric analysis ofimmunohistochemically stained tissue sections, we compared the frequency and distribution of immune cells in palatine tonsils from patientswith recurrent tonsillitis (RT) and patients with idiopathic tonsillar hypertrophy (ITH). We found that differences between the two patientgroups in leucocyte populations were limited to the surface epithelium, whereas the cellular composition of interfollicular and follicular areas was similar. Most intraepithelial lymphocytes were CD8(+) T cells in both groups. However, the number of intraepithelial T cells was significantly higher in RT compared with ITH. This was due to a selective increase in the number of intraepithelial CD8(+) gamma delta T cells utilizing V delta 1 and V gamma 9. In both patient groups the majority of the intraepithelial gamma delta T cells expressed V delta 1 and V gamma 9. Subepithelially, gamma delta T cells utilizing V gamma 9 dominated over cells utilizing V gamma 8, while equal proportions expressed V delta 1 and V delta 2. These results suggest that cells utilizing the otherwise rare combination V delta 1/V gamma 9 in their T cell receptors (TCR) may constitute a major gamma delta T cell population inpalatine tonsils and are probably reactive to antigens specific to the tonsillar milieu. Furthermore, they indicate that preferentially this gamma delta T cell subpopulation is involved in immune reactions within the surface epithelium in RT. We speculate that gamma delta T cells are involved in clearing infectious bacteria at the tonsillar surface and in limiting inflammatory responses in the tonsils. Both local expansion and infiltration of blood cells probably contribute to the high numbers of gamma delta T cells in RT patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 16:36:02