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Titolo:
GLUTAMATE-DECARBOXYLASE ANTIBODIES IN NONDIABETIC PREGNANCY PRECEDES INSULIN-DEPENDENT DIABETES IN THE MOTHER BUT NOT NECESSARILY IN THE OFFSPRING
Autore:
IVARSSON SA; ACKEFORS M; CARLSSON A; EKBERG G; FALORNI A; KOCKUM I; LANDINOLSSON M; LERNMARK A; LINDBERG B; SUNDKVIST G; SVANBERG L;
Indirizzi:
UNIV WASHINGTON,DEPT MED,RH WILLIAMS LAB,BOX 357710 SEATTLE WA 98195 MALMO UNIV HOSP,DEPT PEDIAT S-20502 MALMO SWEDEN
Titolo Testata:
Autoimmunity
fascicolo: 4, volume: 26, anno: 1997,
pagine: 261 - 269
SICI:
0891-6934(1997)26:4<261:GAINPP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISLET-CELL-ANTIBODIES; ACID DECARBOXYLASE; CLINICAL ONSET; HLA-DQ; SWEDISH CHILDREN; CHILDHOOD IDDM; MELLITUS; AUTOANTIBODIES; PREDICTION; DISEASE;
Keywords:
GLUTAMIC ACID DECARBOXYLASE; ISLET CELL AUTOANTIBODIES; AUTOIMMUNITY; PLACENTAL TRANSFER; HLA; PREGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Ivarsson et al., "GLUTAMATE-DECARBOXYLASE ANTIBODIES IN NONDIABETIC PREGNANCY PRECEDES INSULIN-DEPENDENT DIABETES IN THE MOTHER BUT NOT NECESSARILY IN THE OFFSPRING", Autoimmunity, 26(4), 1997, pp. 261-269

Abstract

We studied the risk for diabetes of glutamate decarboxylase (GAD65Ab)and islet cell (ICA) autoantibodies in non-diabetic pregnant mothers and their children. Pregnancy and cord blood sera were collected in 1970-87 from about 35,000 mothers who delivered a child in the city of Malmo, Sweden. A total of 42 mothers were identified in 1988 who, 1-18 years after their pregnancies, had developed either insulin-dependent (n = 22) or non-insulin dependent (n = 20) diabetes mellitus. First, in 123 pregnant mothers selected as controls, 0.8% had GAD65Ab and 0.8%ICA. Second, among the mothers with non-insulin dependent diabetes, 7/20 (35%) had GAD65Ab eight months to 13 years, 10 months before clinical diagnosis. Third, in mothers who later developed insulin-dependentdiabetes, 12/22 (55%) had GAD65Ab and 10/22 (45%) had ICA in pregnancies preceding the clinical diagnosis by 13 months to 9 years, 4 months. In 1996, none of the children born to the 42 mothers have developed diabetes. GAD65Ab and ICA in non-diabetic pregnancies may predict insulin-dependent diabetes in the mother but not necessarily in the offspring.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:54:08