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Titolo:
ACTIVATION OF DEVELOPMENT IN MAMMALS - IS THERE A ROLE FOR A SPERM CYTOSOLIC FACTOR

Autore:

Indirizzi:: UNIV MASSACHUSETTS,DEPT VET & ANIM SCI AMHERST MA 01003
Titolo Testata:: Theriogenology
fascicolo: 1, volume: 49, anno: 1998,
pagine: 43 - 52
SICI:: 0093-691X(1998)49:1<43:AODIM->2.0.ZU;2-6
Fonte:: ISI
Lingua:: ENG
Soggetto:: MOUSE EGG ACTIVATION; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; REPETITIVE CALCIUM TRANSIENTS; GOLDEN-HAMSTER EGGS; CA2+ RELEASE; MEIOTIC MATURATION; OOCYTE ACTIVATION; TYROSINE KINASE; BOVINE EGGS; FERTILIZATION;
Keywords:: CALCIUM; MAMMALIAN EGGS; OSCILLIN; G-PROTEINS; TYROSINE KINASE;
Tipo documento:: Article
Natura:: Periodico
Settore Disciplinare:: Science Citation Index Expanded; Science Citation Index Expanded
Citazioni:: 61
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Citazione:: R.A. Fissore et al., "ACTIVATION OF DEVELOPMENT IN MAMMALS - IS THERE A ROLE FOR A SPERM CYTOSOLIC FACTOR", Theriogenology, 49(1), 1998, pp. 43-52

Abstract

In mammalian oocytes, fertilization-associated calcium [Ca2+](i) oscillations are responsible for the activation of development. The mechanism(s) by which the sperm triggers the initial [Ca2+](i) rise and supports long-lasting oscillations is not resolved. It has been proposed that the sperm may interact with receptors in the oocyte's plasma membrane and engage intracellular signaling pathways that result in Ca2+ release. A different line of investigation suggests that upon sperm-oocyte fusion, a sperm cytosolic factor is released into the oocyte which interacts with unknown cytosolic targets, and generates [Ca2+](i) oscillations. We will discuss the most recent evidence for both lines of thought and demonstrate that injections of sperm crude extracts (SF) into mammalian oocytes trigger [Ca2+](i) oscillations that support in vitro parthenogenetic development to the blastocyst stage. (C) 1998 by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 23:28:57