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Titolo:
EFFECT OF CHRONIC STRESS ON THE SYMPATHETIC COMPONENT OF THE RAT THYMUS
Autore:
MICIC M; ZIVKOVIC I; DJERGOVIC D; KNEZEVIC J; LOVREN M; UGRESIC N;
Titolo Testata:
Acta veterinaria
fascicolo: 5-6, volume: 47, anno: 1997,
pagine: 283 - 291
SICI:
0567-8315(1997)47:5-6<283:EOCSOT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; NERVOUS-SYSTEM; IMMUNE; ENDOCRINE; MIGRATION; CELLS;
Keywords:
RAT THYMUS; CHRONIC STRESS; SYMPATHETIC NERVOUS PROFILES; MONOAMINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Micic et al., "EFFECT OF CHRONIC STRESS ON THE SYMPATHETIC COMPONENT OF THE RAT THYMUS", Acta veterinaria, 47(5-6), 1997, pp. 283-291

Abstract

It is well known that different stressing agents, such as sound exposure, rotation, intermittent shock or forced immobilization, produce alterations of the immune system. Having in mind recent studies about the effects of stress on the immune system, we investigated whether chronic stress induced by a forced swimming procedure alters the sympathetic component of the autonomic nervous system in the rat thymus. For that purpose we exposed AO strain male rats, 22 days old, to a swim testduring 21 days. The experimental animals were divided into two groups, and sacrificed by decapitation, the first group the day after the last treatment, and the second group one month later. Their thymuses were used for determination of the distribution and density of sympathetic nervous profiles, as well as the concentrations of noradrenaline (NA), dopamine (DA), and serotonin (5-HT). When compared with controls, the results for the first group showed that chronic stress did not affect the distribution of sympathetic nervous profiles, but significantlyreduced the density and intensity of fluorescence,as well as the concentrations of NA, DA and 5-HT. The results for the second group showedthe same changes but of lower degree. These changes indicate that chronic stress might influence thymus development and T cell maturation by altering the sympathetic component, and that these altrations persist for one month.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:36:23