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Titolo:
GENETIC-ANALYSIS OF DRUG-ADDICTION - THE ROLE OF CAMP RESPONSE ELEMENT-BINDING PROTEIN
Autore:
BLENDY JA; MALDONADO R;
Indirizzi:
UNIV PENN,SCH MED,DEPT PHARMACOL,3620 HAMILTON WALK PHILADELPHIA PA 19104 FAC PHARM,DEPT PHARMACOCHIM MOL & STRUCT,INSERM,U266 F-75270 PARIS 06FRANCE
Titolo Testata:
Journal of molecular medicine
fascicolo: 2, volume: 76, anno: 1998,
pagine: 104 - 110
SICI:
0946-2716(1998)76:2<104:GOD-TR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR CREB; RAT LOCUS-COERULEUS; NUCLEAR FACTOR CREB; NERVE GROWTH-FACTOR; LONG-TERM-MEMORY; C-FOS; ADENYLATE-CYCLASE; OPIATE WITHDRAWAL; CHRONIC MORPHINE; TARGETED MUTATION;
Keywords:
CAMP RESPONSE ELEMENT BINDING PROTEIN; MORPHINE; WITHDRAWAL SYNDROME; GENE TARGETING; ANIMAL MODELS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Blendy e R. Maldonado, "GENETIC-ANALYSIS OF DRUG-ADDICTION - THE ROLE OF CAMP RESPONSE ELEMENT-BINDING PROTEIN", Journal of molecular medicine, 76(2), 1998, pp. 104-110

Abstract

Many drugs of abuse, administered repeatedly over timer cause physical dependence which is expressed by a withdrawal syndrome when the drugis removed from the system. These processes can be thought of as adaptations of the neuronal system to an altered pharmacological state. The molecular mechanisms underlying these adaptations are still not known. A considerable amount of evidence is accumulating which implicates alterations in several components of the cAMP signal transduction cascade in these drug-induced processes, The transcription factor cAMP response element binding protein (CREB) in particular has been shown bothin vitro and in vivo to be altered in response to several drugs of abuse, including opiates. This review discusses in detail this transcription factor and demonstrates its importance in the signal transductioncascades involving abused substances.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:15:19