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Titolo:
FAMILY HISTORY AS A RISK FACTOR FOR PRIMARY CARDIAC-ARREST
Autore:
FRIEDLANDER Y; SISCOVICK DS; WEINMANN S; AUSTIN MA; PSATY BM; LEMAITRE RN; ARBOGAST P; RAGHUNATHAN TE; COBB LA;
Indirizzi:
UNIV WASHINGTON,DEPT MED,CARDIOVASC HLTH RES UNIT,METROPOLITAN PK 2 BLDG,SUITE 1360 SEATTLE WA 98101 UNIV WASHINGTON,DEPT MED,CARDIOVASC HLTH RES UNIT SEATTLE WA 98101 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98101 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98101 UNIV MICHIGAN,INST SOCIAL RES ANN ARBOR MI 00000 HEBREW UNIV JERUSALEM,HADASSAH SCH PUBL HLTH,DEPT SOCIAL MED JERUSALEM ISRAEL
Titolo Testata:
Circulation
fascicolo: 2, volume: 97, anno: 1998,
pagine: 155 - 160
SICI:
0009-7322(1998)97:2<155:FHAARF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; SUDDEN UNEXPECTED DEATH; MYOCARDIAL-INFARCTION; ARTERY DISEASE; PARENTAL HISTORY; MEN; WOMEN; EPIDEMIOLOGY; AGE;
Keywords:
RISK FACTORS; HEART ARREST; MYOCARDIAL INFARCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
Y. Friedlander et al., "FAMILY HISTORY AS A RISK FACTOR FOR PRIMARY CARDIAC-ARREST", Circulation, 97(2), 1998, pp. 155-160

Abstract

Background-The hypothesis that a family history of myocardial infarction (MI) or primary cardiac arrest (PCA) is an independent risk factorfor primary cardiac arrest was examined in a population-based case-control study. In addition, we investigated whether recognized risk factors account for the familial aggregation of these cardiovascular events. Methods and Results-PCA cases, 25 to 74 years old, attended by paramedics during the period 1988 to 1994 and population-based control subjects matched for age and sex were identified from the community by random digit dialing. All subjects were free of recognized clinical heart disease and major comorbidity. A detailed history of MI and PCA in first-degree relatives was collected in interviews with the spouses of case and control subjects by trained interviewers using a standardizedquestionnaire. For each familial relationship, there was a higher rate of MI or primary cardiac arrest (MI/PCA) in relatives of case compared with relatives of control subjects. Overall, the rate of MI/PCA among first-degree relatives of cardiac arrest patients was almost 50% higher than that in first-degree relatives of control subjects (rate ratio [RR]=1.46; 95% CI=1.23 to 1.72). In a multivariate logistic model, family history of MI/PCA was associated with PCA (RR=1.57, 95% CI=1.27to 1.95) even after adjustment for other common risk factors. Conclusions-Family history of MI or PCA is positively associated with the risk of primary cardiac arrest. This association is mostly independent offamilial aggregation of other common risk factors.

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Documento generato il 27/11/20 alle ore 02:10:55