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Titolo:
ALCOHOL-RELATED SUDDEN-DEATH WITH HEPATIC FATTY METAMORPHOSIS - A COMPREHENSIVE CLINICOPATHOLOGICAL INQUIRY INTO ITS PATHOGENESIS
Autore:
YUZURIHA T; OKUDAIRA M; TOMINAGA I; HORI S; SUZUKI H; MATSUO Y; SHOJI M; YOKOYAMA A; TAKAGI S; HAYASHIDA M;
Indirizzi:
HIZEN NATL MENTAL HOSP KANZAKI,CTR EMOT & BEHAV DISORDERS SAGA 84201 JAPAN KURIHAMA NATL HOSP,NATL INST ALCOHOLISM KANAGAWA JAPAN TOKYO METROPOLITAN MED EXAMINERS OFF TOKYO JAPAN KEIO UNIV,EMERGENCY DEPT TOKYO JAPAN SAITAMA MED COLL,RENAL DIS & DIALYSIS CTR MOROYAMA SAITAMA JAPAN
Titolo Testata:
Alcohol and alcoholism
fascicolo: 6, volume: 32, anno: 1997,
pagine: 745 - 752
SICI:
0735-0414(1997)32:6<745:ASWHFM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER; KETOACIDOSIS; MORTALITY; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
T. Yuzuriha et al., "ALCOHOL-RELATED SUDDEN-DEATH WITH HEPATIC FATTY METAMORPHOSIS - A COMPREHENSIVE CLINICOPATHOLOGICAL INQUIRY INTO ITS PATHOGENESIS", Alcohol and alcoholism, 32(6), 1997, pp. 745-752

Abstract

To clarify the pathogenesis of the widely known but obscure syndrome of sudden death with hepatic fatty metamorphosis observed in alcohol abusers, we have scrutinized both the clinical and pathological data of11 subjects who died under such circumstances between 1987 and 1993. Death followed several days of uninterrupted drinking often with little dietary intake. The notable clinical features on arrival at the emergency room were disturbance of consciousness (11/11), hypotension (4/6), hypothermia (3/5), hypoglycaemia (8/11), metabolic acidosis (6/6), renal dysfunction (11/11), and hyperammonaemia (5/5). The common hepatic pathology was the extensive appearance of numerous microvesicular fatty droplets in the hepatocytes together with varying degrees of macrovesicular fatty change; four subjects had an underlying cirrhosis. Death undoubtedly results from a variety of metabolic disturbances triggered by the combination of massive ethanol intake and starvation. The appearance of extensive microvesicular fatty change superimposed on macrovesicular fatty change was considered to be an associated phenomenon.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:45:30