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Titolo:
DIFFERENTIAL MODULATION OF ADENYLYL-CYCLASE-I AND ADENYLYL-CYCLASE-IIBY VARIOUS G(BETA) SUBUNITS
Autore:
BAYEWITCH ML; AVIDORREISS T; LEVY R; PFEUFFER T; NEVO I; SIMONDS WF; VOGEL Z;
Indirizzi:
WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL UNIV DUSSELDORF,DEPT PHYSIOL CHEM 2 D-40225 DUSSELDORF GERMANY NIDDK,METAB DIS BRANCH,NIH BETHESDA MD 20892
Titolo Testata:
The Journal of biological chemistry
fascicolo: 4, volume: 273, anno: 1998,
pagine: 2273 - 2276
SICI:
0021-9258(1998)273:4<2273:DMOAAA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-GAMMA-SUBUNITS; G-PROTEINS; CELLS; EXPRESSION; BRAIN; RESPONSIVENESS; PURIFICATION; ACTIVATION; DIVERSITY; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Bayewitch et al., "DIFFERENTIAL MODULATION OF ADENYLYL-CYCLASE-I AND ADENYLYL-CYCLASE-IIBY VARIOUS G(BETA) SUBUNITS", The Journal of biological chemistry, 273(4), 1998, pp. 2273-2276

Abstract

The accepted dogma concerning the regulation of adenylyl cyclase (AC)activity by G(beta gamma) dimers states that the various isoforms of AC respond differently to the presence of free G(beta gamma) It has been demonstrated that AC I activity is inhibited and AC II activity is stimulated by G(beta gamma) subunits, This result does not address thepossible G differences in modulation that may exist among the different G(beta gamma) heterodimers, Six isoforms of G(beta) and 12 isoformsof G(gamma) have been cloned to date, We have established a cell transfection system in which G(beta) and G(gamma) cDNAs were cotransfectedwith either AC isoform I or II and the activity of these isoforms wasdetermined, We found that while AC I activity was inhibited by both G(beta 1/gamma 2) and G(beta 5/gamma 2) combinations, AC II responded differentially and was stimulated by G(beta 1/gamma 2). This finding demonstrates differential modulatory activity by different combinations of G(beta gamma) on the same AC isoform and demonstrates another levelof complexity within the AC signaling system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 05:57:44