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Titolo:
JH GENE SEQUENCE-ANALYSIS IN A PATIENT WITH WALDENSTROMS MACROGLOBULINEMIA WITH SUBSEQUENT DEVELOPMENT OF IMMUNOBLASTIC LYMPHOMA
Autore:
KONDO H; YUMOTO N; MIKATA A; DATE Y;
Indirizzi:
SHIMIZU KOUSEI HOSP,DEPT MED,DIV HAEMATOL & ONCOL,578-1 IHARA CHO SHIMIZU SHIZUOKA 42401 JAPAN CHIBA UNIV,SCH MED,DEPT PATHOL 1 CHIBA 280 JAPAN
Titolo Testata:
JCP. Clinical molecular pathology
fascicolo: 4, volume: 48, anno: 1995,
pagine: 215 - 218
SICI:
1355-2910(1995)48:4<215:JGSIAP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC LYMPHOCYTIC-LEUKEMIA;
Keywords:
WALDENSTROMS MACROGLOBULINEMIA; IMMUNOBLASTIC LYMPHOMA; TRANSFORMATION; JH GENE SEQUENCE ANALYSIS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
H. Kondo et al., "JH GENE SEQUENCE-ANALYSIS IN A PATIENT WITH WALDENSTROMS MACROGLOBULINEMIA WITH SUBSEQUENT DEVELOPMENT OF IMMUNOBLASTIC LYMPHOMA", JCP. Clinical molecular pathology, 48(4), 1995, pp. 215-218

Abstract

A case of Waldenstrom's macroglobulinaemia with subsequent development of immunoblastic lymphoma in a 69 year old man is reported. Plasmacytoid lymphocytes were initially observed in both peripheral blood and bone marrow smears. Lymph node biopsy was interpreted as malignant lymphoma, diffuse mixed cell type compatible with Waldenstrom's macroglobulinaemia. Complete remission resulted on combined treatment with prednisolone and melphalan. Four years later, lymphadenopathy recurred andbiopsy revealed the development of an immunoblastic lymphoma. Initially, this lymphoma was thought to be the malignant transformation of Waldenstrom's microglobulinaemia, because both tumours produced IgM (kappa light chains). Sequencing of immunoglobulin heavy chain genes of Waldenstrom's macroglobulinaemia and immunoblastic lymphoma cells, however, revealed different DH and JH usage between the two, indicating theindependent nature of the two haematological malignancies. These results indicate that clonality of primary and secondary tumours should bedetermined not by phenotypic, but by genotypic analysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:18:42