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Titolo:
KERATINOCYTE GROWTH-FACTOR IN THE RAT VENTRAL PROSTATE - ANDROGEN-INDEPENDENT EXPRESSION
Autore:
NEMETH JA; ZELNER DJ; LANG S; LEE C;
Indirizzi:
NORTHWESTERN UNIV,SCH MED,DEPT UROL,TARRY 11-715,303 E CHICAGO AVE CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT UROL CHICAGO IL 60611
Titolo Testata:
Journal of Endocrinology
fascicolo: 1, volume: 156, anno: 1998,
pagine: 115 - 125
SICI:
0022-0795(1998)156:1<115:KGITRV>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CASTRATION-INDUCED INVOLUTION; EPITHELIAL-CELLS; PLASMINOGEN-ACTIVATOR; EXTRACELLULAR-MATRIX; GENE-EXPRESSION; REGIONAL VARIATION; ENDOTHELIAL-CELLS; DUCTAL SYSTEM; FIBROBLAST; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Nemeth et al., "KERATINOCYTE GROWTH-FACTOR IN THE RAT VENTRAL PROSTATE - ANDROGEN-INDEPENDENT EXPRESSION", Journal of Endocrinology, 156(1), 1998, pp. 115-125

Abstract

Keratinocyte growth factor (KGF/FGF-7) is a stromally derived factor which exerts proliferative and differentiating effects on a variety ofepithelial cells. Results of recent studies utilizing ill vitro methods such as tissue culture and organ culture have suggested chat KGF may act as a paracrine mediator of androgen-induced growth and development of the prostate and seminal vesicle, We undertook the present studyto determine tile distribution oi KGF in relation to the functional regions of the me prostatic ductal system, and whether KGF expression is influenced by androgen in vivo. Immunohistochemical staining revealed IGF to be present in the stroma throughout the prostate, regardless of the functional region and staining for KGF remained high through 21days post-castration. Message for KGF could also be detected by reverse transcriptase-PCR analysis of prostate stromal cells isolated from 4- and 21-day castrated animals, and Ilo gross change in mes:;age level was observed following castration. Furthermore, no significant: change in either stromal staining or message for KGF was observed ill newborn rat prostates 10 days after castration, suggesting a similar regulatory mechanism for KGF in the adult and immature prostate. Epithelialstaining for KGF: decreased following castration, and greatly increased upon androgen replacement, possibly indicating a change in KGF internalization. These observations suggest that the presence of KGF protein is not related to functional differences in the prostate epithelium, and that expression of KGF in vivo is not greatly influenced by androgen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:51:58