Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EPINEPHRINE ABSORPTION IN CHILDREN WITH A HISTORY OF ANAPHYLAXIS
Autore:
SIMONS FER; ROBERTS JR; GU XC; SIMONS KJ;
Indirizzi:
CHILDRENS HOSP,820 SHERBROOK ST WINNIPEG MB R3A 1R9 CANADA UNIV MANITOBA,FAC MED,DEPT PEDIAT & CHILD HLTH,ALLERGY & CLIN IMMUNOLSECT WINNIPEG MB CANADA UNIV MANITOBA,FAC PHARM,DIV PHARMACEUT SCI WINNIPEG MB CANADA
Titolo Testata:
Journal of allergy and clinical immunology
fascicolo: 1, volume: 101, anno: 1998,
parte:, 1
pagine: 33 - 37
SICI:
0091-6749(1998)101:1<33:EAICWA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOD;
Keywords:
EPINEPHRINE ABSORPTION; SUBCUTANEOUS/INTRAMUSCULAR INJECTION; CHILDREN; SYSTEMIC ANAPHYLAXIS; FOOD/VENOM ALLERGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
F.E.R. Simons et al., "EPINEPHRINE ABSORPTION IN CHILDREN WITH A HISTORY OF ANAPHYLAXIS", Journal of allergy and clinical immunology, 101(1), 1998, pp. 33-37

Abstract

Background: Prompt injection of epinephrine is the cornerstone of systemic anaphylaxis treatment. The rate of epinephrine absorption has not been reported previously in allergic children. Objective: Our objective was to study the clinical pharmacology of epinephrine in this population. Methods: We performed a prospective, randomized, blinded, parallel-group study in 17 children with a history of anaphylaxis to food. Hymenoptera venom, or other substances. We injected 0.01 ml/kg epinephrine solution (maximum 0.3 ml [0.3 mg]) subcutaneously, or 0.3 mg epinephrine intramuscularly from an autoinjector. Plasma epinephrine concentrations, heart rate, blood pressure, and adverse effects were monitored. Results: In nine children who received epinephrine subcutaneously, the mean maximum plasma epinephrine concentration (+/- SEM) was 1802 +/- 214 pg/ml, achieved at a mean time of 34 +/- 14 minutes (range, 5 to 120 minutes). Only two of the nine children achieved maximum plasma concentrations by 5 minutes. In eight children who received epinephrine intramuscularly, the mean maximum plasma concentration was 2136 +/- 351 pg/ml, achieved at a mean time of 8 +/- 2 minutes, which was significantly faster than the mean time at which maximum plasma concentrations were achieved after subcutaneous epinephrine injection (p < 0.05). Six of the eight children achieved maximum plasma concentrations by 5 minutes. The terminal elimination half-life was 43 +/- 15 minutes. No serious adverse effects were noted in any child. Conclusions: In children, recommendations for subcutaneous epinephrine injection are based on anecdotal experience, and should be reevaluated in view of our finding of delayed epinephrine absorption when this route is used. This delay might have important clinical implications during an episode of systemic anaphylaxis. The intramuscular route of injection is preferable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 15:22:26