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Titolo:
STRINGENT CRITERIA FOR HISTOLOGICAL DIAGNOSIS OF KOILOCYTOSIS FAIL TOELIMINATE OVERDIAGNOSIS OF HUMAN-PAPILLOMAVIRUS INFECTION AND CERVICAL INTRAEPITHELIAL NEOPLASIA GRADE-1
Autore:
ABADI MA; HO GYF; BURK RD; ROMNEY SL; KADISH AS;
Indirizzi:
ALBERT EINSTEIN COLL MED,DEPT PATHOL,1300 MORRIS PK AVE BRONX NY 10461 ALBERT EINSTEIN COLL MED,DEPT PATHOL BRONX NY 10461 ALBERT EINSTEIN COLL MED,DEPT EPIDEMIOL & SOCIAL MED BRONX NY 10461 ALBERT EINSTEIN COLL MED,DEPT PEDIAT BRONX NY 10461 ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL BRONX NY 10461 ALBERT EINSTEIN COLL MED,DEPT OBSTET & GYNECOL BRONX NY 10461
Titolo Testata:
Human pathology
fascicolo: 1, volume: 29, anno: 1998,
pagine: 54 - 59
SICI:
0046-8177(1998)29:1<54:SCFHDO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS INFECTION; INSITU HYBRIDIZATION; RISK-FACTORS; BETHESDA SYSTEM; GENITAL CANCER; FOLLOW-UP; LESIONS; WOMEN; DNA; CLASSIFICATION;
Keywords:
HUMAN PAPILLOMAVIRUS; CERVICAL INTRAEPITHELIAL NEOPLASIA; KOILOCYTOSIS; SQUAMOUS INTRAEPITHELIAL LESION; OVERDIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Abadi et al., "STRINGENT CRITERIA FOR HISTOLOGICAL DIAGNOSIS OF KOILOCYTOSIS FAIL TOELIMINATE OVERDIAGNOSIS OF HUMAN-PAPILLOMAVIRUS INFECTION AND CERVICAL INTRAEPITHELIAL NEOPLASIA GRADE-1", Human pathology, 29(1), 1998, pp. 54-59

Abstract

Overdiagnosis of HPV infection in cervical biopsies results in increased health care costs and unnecessary surgical procedures. Stringent criteria for histological diagnosis of koilocytosis were evaluated, using molecular detection of HPV DNA (polymerase chain reaction and Southern blot hybridization) as gold standard. Colposcopic biopsy specimensfrom 511 patients were studied, including 76 with referral diagnoses of negative cervix and 241 with CIN 1 or koilocytosis. Referral diagnoses for low-grade lesions failed to distinguish between HPV-infected and uninfected patients. False-positive rate for prediction of HPV infection was 74.8%. Biopsy specimens reevaluated using stringent diagnostic criteria showed increasing prevalence of HPV infection among patients whose biopsy specimens showed negative (43.7%), minimal (52.4%), ordefinite (69.5%) features of koilocytosis (P = .001). Similarly, subjects infected with high viral load or oncogenic HPV infection were more likely to be identified (P = .004 and .04, respectively). Despite increased predictive value of stringent diagnostic criteria, significantnumber of patients diagnosed as having CIN 1/koilocytosis (34.0%) didnot in fact have HPV infection. Because most low-grade lesions spontaneously regress, patients with histological diagnosis of CIN 1 or HPV infection should be observed for a period of several months before definitive ablative treatment is undertaken. Copyright (C) 1998 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:53:28