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Titolo:
TREATMENT OF SEVERE CLOZAPINE-INDUCED NEUTROPENIA WITH GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) - REMISSION DESPITE CONTINUOUS TREATMENT WITH CLOZAPINE
Autore:
SPERNERUNTERWEGER B; CZEIPEK I; GAGGL S; GEISSLER D; SPIEL G; FLEISCHHACKER WW;
Indirizzi:
INNSBRUCK UNIV CLIN,DEPT BIOL PSYCHIAT A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV CLIN,DEPT INTERNAL MED A-6020 INNSBRUCK AUSTRIA STATE HOSP KLAGENFURT,DEPT INTERNAL MED A-9020 KLAGENFURT AUSTRIA STATE HOSP KLAGENFURT,DEPT PEDIAT PSYCHIAT A-9020 KLAGENFURT AUSTRIA
Titolo Testata:
British Journal of Psychiatry
, volume: 172, anno: 1998,
pagine: 82 - 84
SICI:
0007-1250(1998)172:<82:TOSCNW>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED AGRANULOCYTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
B. Spernerunterweger et al., "TREATMENT OF SEVERE CLOZAPINE-INDUCED NEUTROPENIA WITH GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) - REMISSION DESPITE CONTINUOUS TREATMENT WITH CLOZAPINE", British Journal of Psychiatry, 172, 1998, pp. 82-84

Abstract

Background A 17-year-old boy suffering from a severe schizophrenic disorder of the paranoid type and mental retardation did not respond to treatment with typical antipsychotics, whereas under clozapine treatment he showed a favourable response. Discontinuation of clozapine led to an acute psychotic relapse. During clozapine treatment the patient developed severe neutropenia. Method and Results Due to the history of unsatisfactory response to traditional antipsychotics, clozapine treatment was continued despite white blood cell (WBC) decline. Concomitanttreatment with G-CSF was followed by a rapid normalisation of WBC. Conclusions This case report is not intended to challenge the clinical practice of discontinuing clozapine upon the development of neutropenia/agranulocytosis, but rather to stimulate further research in the pathophysiology and clinical consequences of a clozapine rechallenge aftera WBC decline, especially in patients with a rather complex symptomatology where no sufficient therapeutic results can be achieved with anyother pharmacological intervention than clozapine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:35:46