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Titolo:
THE EFFECT OF PREDNISOLONE AND NONSTEROIDAL ANTIINFLAMMATORY AGENTS ON THE NORMAL AND NOISE-DAMAGED GUINEA-PIG INNER-EAR
Autore:
LAMM K; ARNOLD W;
Indirizzi:
TECH UNIV MUNICH,KLINIKUM RECHTS ISAR,DEPT OTOLARYNGOL HEAD & NECK SURG,ISMANINGER STR 22 D-81675 MUNICH GERMANY
Titolo Testata:
Hearing research
fascicolo: 1-2, volume: 115, anno: 1998,
pagine: 149 - 161
SICI:
0378-5955(1998)115:1-2<149:TEOPAN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORINEURAL HEARING-LOSS; BLOOD-CELL VELOCITY; GLUCOCORTICOID RECEPTORS; RAT COCHLEA; VESTIBULAR TISSUES; BINDING-SITES; THERAPY; VASCULATURE; REAPPRAISAL; EXPRESSION;
Keywords:
COCHLEA; HEARING LOSS, NOISE-INDUCED; DRUG EFFECT; PREDNISOLONE; DICLOFENAC; HISTAMINE ANTAGONIST; AUDITORY EVOKED POTENTIAL; BRAIN STEM EVOKED POTENTIAL; ELECTROCOCHLEOGRAPHY; COCHLEAR BLOOD FLOW; LASER DOPPLER FLOWMETRY; PERILYMPH PO(2); HYPOXIA; GUINEA PIG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
K. Lamm e W. Arnold, "THE EFFECT OF PREDNISOLONE AND NONSTEROIDAL ANTIINFLAMMATORY AGENTS ON THE NORMAL AND NOISE-DAMAGED GUINEA-PIG INNER-EAR", Hearing research, 115(1-2), 1998, pp. 149-161

Abstract

The effect of anti-inflammatory agents, such as the synthetic glucocorticoid prednisolone, diclofenac sodium, and histamine H1-receptor antagonist, was studied in unexposed and noise-exposed (broad-band noise,bandwidth 1-12 kHz, 106 dB SPL, 30 min) guinea pigs. The results werecompared with the results obtained from no treatment and with isotonic saline (placebo) therapy. The cochlear blood flow (CoBF) and the partial oxygen pressure in the perilymph (PL-pO(2)) were continuously andsimultaneously recorded over a period of 210 min. In addition, cochlear microphonics (CMs), compound action potentials of the auditory nerve (CAPs), and auditory brain stem responses (ABRs) were registered. Noise-induced hearing loss paralleled a decrease of PL-pO(2). Both were found to occur before evidence of reduced CoBF. PL-pO(2) and CoBF progressively declined post-exposure, while CMs, CAPs, and ABRs did not further deteriorate nor showed signs of recovery up to 180 min after cessation of noise. Treatment started 60 min post-exposure, or after 90 mill without manipulation and was then Further studied for 120 min. In the unexposed animals, diclofenac sodium and prednisolone induced a significant decline of PL-pO(2), while CoBF, CMs, CAPs, and ABRs revealed no change. Isotonic saline did not influence the measured parameters. After infusion of the histamine H1-receptor antagonist, a significant decrease of CoBF together with blood pressure and CMs was observed, while PL-pO(2), CAPs, and ABRs showed no change. In the noise-exposed animals, diclofenac sodium induced partial restoration of CM and CAP amplitudes and full restoration of ABRs. Following a high dose of prednisolone (25 mg), partial restoration of CMs and full restoration of CAPs and ABRs were registered. This effect was significantly less pronounced following a low dose of prednisolone (2.5 mg). Restoration of CMs, CAPs, and ABRs was immediate (i.e. 50 min after infusion) and remained stable for another 60 min until the end of the recording period. The histamine HI-receptor antagonist and isotonic saline did not influence CMs, CAPs, and ABRs. None of the applied drugs resulted in relief of progressive noise-induced cochlear hypoxia and post-traumatic ischemia. These findings indicate direct cellular effects of prednisolone and diclofenac sodium in the cochlea taking into account no blood flow and oxygenation. The possible mechanisms involved are discussed. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:24:17