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Titolo:
INPUTS TO A PHYSIOLOGICALLY CHARACTERIZED REGION OF THE INFERIOR COLLICULUS OF THE YOUNG-ADULT CBA MOUSE
Autore:
FRISINA RD; WALTON JP; LYNCHARMOUR MA; BYRD JD;
Indirizzi:
UNIV ROCHESTER,SCH MED & DENT,DEPT SURG,OTOLARYNGOL DIV,601 ELMWOOD AVE ROCHESTER NY 14642 UNIV ROCHESTER,SCH MED & DENT,DEPT PHYSIOL ROCHESTER NY 14642
Titolo Testata:
Hearing research
fascicolo: 1-2, volume: 115, anno: 1998,
pagine: 61 - 81
SICI:
0378-5955(1998)115:1-2<61:ITAPCR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR OLIVARY COMPLEX; DORSAL COCHLEAR NUCLEUS; ASCENDING PROJECTIONS; HEARING-LOSS; FREQUENCY REPRESENTATION; FUNCTIONAL-ORGANIZATION; EFFERENT PROJECTIONS; PTERONOTUS-PARNELLII; LATERAL LEMNISCUS; AUDITORY-SYSTEM;
Keywords:
HEARING; DEAFNESS; AGING; HORSERADISH PEROXIDASE; CENTRAL AUDITORY SYSTEM; TRACT TRACING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Frisina et al., "INPUTS TO A PHYSIOLOGICALLY CHARACTERIZED REGION OF THE INFERIOR COLLICULUS OF THE YOUNG-ADULT CBA MOUSE", Hearing research, 115(1-2), 1998, pp. 61-81

Abstract

Presbycusis is a sensory perceptual disorder involving loss of high-pitch hearing and reduced ability to process biologically relevant acoustic signals in noisy environments. The present investigation is part of an ongoing series of studies aimed at discerning the neural bases of presbycusis. The purpose of the present experimen: was to delineate the inputs to a functionally characterized region of the dorsomedial inferior colliculus (IC, auditory midbrain) in young, adult CBA mice. Focal, iontophoretic injections of horseradish peroxidase were made illthe 18-24 kHz region of dorsomedial IC of the CBA strain following physiological mapping experiments. Serial sections were reacted with diaminobenzidine or tetramethylbenzidine, counterstained and examined forretrogradely labeled cell bodies. Input projections were observed contralaterally: from: all three divisions of cochlear nucleus, intermediate and dorsal nuclei of the lateral lemniscus (LL); and the central nucleus, external nucleus and dorsal cortex of the IC. Input projections were observed ipsilaterally from: the medial and lateral superior olivary nuclei; the superior paraolivary nucleus; the dorsolateral and anterolateral periolivary nuclei; the dorsal and ventral divisions of the ventral nucleus of LL; the dorsal and intermediate nuclei of LL; the central nucleus, external nucleus and dorsal cortex of the IC outside the injection site; and small projections from central gray and the medial geniculate body. These findings in young, adult mice with normal hearing call now serve as a baseline for similar experiments being conducted in mice of older ages and with varying degrees of hearing loss to discover neural changes that may cause age-related hearing disorders. (C) 1998 Elsevier Science B.V.

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Documento generato il 23/09/20 alle ore 11:54:19