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Titolo:
MYOCARDIAL PRESYNAPTIC AND POSTSYNAPTIC AUTONOMIC DYSFUNCTION IN HYPERTONIC CARDIOMYOPATHY
Autore:
SCHAFERS M; DUTKA D; RHODES CG; LAMMERTSMA AA; HERMANSEN F; SCHOBER O; CAMICI PG;
Indirizzi:
HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT,DUCANE RD LONDON W12 0NN ENGLAND HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT LONDON W12 0NN ENGLAND UNIV LONDON SCH PHARM,SCH MED LONDON ENGLAND UNIV MUNSTER,DEPT NUCL MED D-4400 MUNSTER GERMANY
Titolo Testata:
Circulation research
fascicolo: 1, volume: 82, anno: 1998,
pagine: 57 - 62
SICI:
0009-7330(1998)82:1<57:MPAPAD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; MYOSIN HEAVY-CHAIN; CORONARY-ARTERY DISEASE; I-123 METAIODOBENZYLGUANIDINE; CLINICAL MANIFESTATIONS; BETA-ADRENOCEPTORS; PATHO-PHYSIOLOGY; MOLECULAR-BASIS; HUMAN HEART;
Keywords:
CARDIOMYOPATHY, HYPERTROPHIC; AUTONOMIC DYSFUNCTION; CATECHOLAMINES; BETA ADRENOCEPTORS; POSITRON EMISSION TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M. Schafers et al., "MYOCARDIAL PRESYNAPTIC AND POSTSYNAPTIC AUTONOMIC DYSFUNCTION IN HYPERTONIC CARDIOMYOPATHY", Circulation research, 82(1), 1998, pp. 57-62

Abstract

Although hypertrophic cardiomyopathy (HCM) is genetically determined,several other factors, including autonomic dysfunction, may play a role in the phenotypic expression. A recent study using positron emission tomography with [C-11]CGP12177([C-11]CGP) demonstrated that beta-adrenoceptor (beta AR) density is reduced in HCM and is correlated with disease progression, This present study tested the hypothesis that thisdownregulation is associated with reduced catecholamine reuptake (uptake 1) by myocardial sympathetic nerve terminals leading to increased local norepinephrine concentration. Myocardial presynaptic catecholamine reuptake was assessed by measuring the volume of distribution (V-d)of the catecholamine analogue [C-11]hydroxyephedrine ([C-11]HED) in 9unrelated HCM patients aged 45 +/- 15 years. The maximum number of binding sites (B-max) for myocardial beta AR density was measured in 13 unrelated HCM patients aged 40 +/- 12 years using the nonselective beta blocker [C-11]CGP. Six patients were studied with both [C-11]HED and[C-11]CGP. Comparison was made with two groups of healthy control subjects for each ligand ([C-11]HED, n = 10, aged 35 +/- 8 years; [C-11]CGP, n = 19, aged 44 +/- 16 years). Myocardial V-d of [C-11]HED (33.4 +/- 4.3 mL/g tissue) and beta AR density (7.3 +/- 2.6 pmol/g tissue) were significantly reduced in HCM patients compared with control subjects (71.0 +/- 18.8 mL/g tissue, P < .001, and 10.2 +/- 2.9 pmol/g tissue, P = .008, respectively). These results are consistent with our hypothesis that myocardial beta AR downregulation in HCM is associated withan impaired uptake-1 mechanism and hence increased local catecholamine levels.

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Documento generato il 31/10/20 alle ore 00:07:34