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Titolo:
CORRELATION OF NEUROPSYCHOLOGICAL, MORPHOLOGICAL AND FUNCTIONAL (REGIONAL CEREBRAL BLOOD-FLOW AND GLUCOSE-UTILIZATION) FINDINGS IN CEREBRALMICROANGIOPATHY
Autore:
SABRI O; HELLWIG D; SCHRECKENBERGER M; CREMERIUS U; SCHNEIDER R; KAISER HJ; DOHERTY C; MULL M; RINGELSTEIN EB; BUELL U;
Indirizzi:
RHEIN WESTFAL TH AACHEN,DEPT NUCL MED,PAUWELSSTR 30 D-52057 AACHEN GERMANY RHEIN WESTFAL TH AACHEN,DEPT NEUROL D-52057 AACHEN GERMANY RHEIN WESTFAL TH AACHEN,DEPT NEURORADIOL D-52057 AACHEN GERMANY UNIV MUNSTER,DEPT NEUROL D-4400 MUNSTER GERMANY
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 1, volume: 39, anno: 1998,
pagine: 147 - 154
SICI:
0161-5505(1998)39:1<147:CONMAF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE-MATTER LESIONS; VASCULAR DEMENTIA; BINSWANGERS-DISEASE; LEUKO-ARAIOSIS; METABOLIC-RATE; AGING BRAIN; LEUKOARAIOSIS; ATROPHY; ENCEPHALOPATHY; INFARCTIONS;
Keywords:
CEREBRAL MICROANGIOPATHY; TECHNETIUM-99M-HMPAO SPECT; FLUORINE-18-FDG PET; MRI; NEUROPSYCHOLOGICAL TESTING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
O. Sabri et al., "CORRELATION OF NEUROPSYCHOLOGICAL, MORPHOLOGICAL AND FUNCTIONAL (REGIONAL CEREBRAL BLOOD-FLOW AND GLUCOSE-UTILIZATION) FINDINGS IN CEREBRALMICROANGIOPATHY", The Journal of nuclear medicine, 39(1), 1998, pp. 147-154

Abstract

Cerebral microangiopathy, indicated in MRI by lacunar infarctions (LIs) and deep white matter lesions (DWMLs), is said to be accompanied byvascular dementia, which is reportedly caused by LI and DWML. Methods: To confirm this assumption, 57 patients with cerebral microangiopathy were assessed for changes in regional cerebral blood flow (rCBF) andglucose utilization (rMRGlu) in both white matter and cortex, and these findings were correlated to the results of extensive neuropsychological testing (cognitive, mnestic and attentiveness tests), as well as to MRI findings. A special head holder ensured reproducibility of positioning during measurement of rCBF (Tc-99m-HMPAO SPECT) and rMRGlu (F-18-FDG PET) and MRI. White matter and cortex were quantified with regions of interest defined on MRI and superimposed to corresponding PET/SPECT slices. The rMRGlu was calculated according to Sokoloff, and rCBFwas determined from normalization to the cerebellum. LI and DWML weregraded by number and extent. Brain atrophy was classified as no to slight inner and/or outer atrophy (Group A) or moderate-to-severe inner and outer atrophy (Group B). Results: Even in severe DWMLs and in multiple LIs, rCBFs and rMRGlu values were not reduced. Analysis of variance identified atrophy and neuropsychological deficits as the main determinants for reduced rCBF and rMRGlu values (p < 0.05). However, 60% of patients (19 of 31) with neuropsychological deficits in attentiveness tests and 61% of patients (23 of 38) with mnestic deficits belonged to Group A and revealed decreased rCBF and rMRGlu values. Neuropsychological deficits correlated well with decreased rCBF and rMRGlu, whereas MRI patterns, such as LI and DWML, did not. Conclusion: We conclude that LI and DWML are epiphenomena that morphologically characterize cerebral microangiopathy. Dementia or neuropsychological deficits, however, are exclusively reflected by functional criteria (rCBF and rMRGlu), as long as cerebral atrophy does not occur.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:27:09