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Titolo:
DIAGNOSIS OF RECURRENT GLIOMA WITH SPECT AND IODINE-123-ALPHA-METHYL TYROSINE
Autore:
KUWERT T; WOESLER B; MORGENROTH C; LERCH H; SCHAFERS M; PALKOVIC S; MATHEJA P; BRANDAU W; WASSMANN H; SCHOBER O;
Indirizzi:
UNIV MUNSTER,DEPT NUCL MED,ALBERT SCHWEITZER STR 33 D-48129 MUNSTER GERMANY UNIV MUNSTER,DEPT NEUROSURG D-48129 MUNSTER GERMANY
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 1, volume: 39, anno: 1998,
pagine: 23 - 27
SICI:
0161-5505(1998)39:1<23:DORGWS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ALPHA-METHYL TYROSINE; AMINO-ACID-TRANSPORT; BRAIN-TUMORS; F-18 FLUORODEOXYGLUCOSE; L-3-)I-123>IODO-ALPHA-METHYL TYROSINE; COMPUTED-TOMOGRAPHY; PET; LESIONS;
Keywords:
SPECT; IODINE-123-ALPHA-METHYL TYROSINE; AMINO ACIDS; BRAIN NEOPLASMS; GLIOMAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T. Kuwert et al., "DIAGNOSIS OF RECURRENT GLIOMA WITH SPECT AND IODINE-123-ALPHA-METHYL TYROSINE", The Journal of nuclear medicine, 39(1), 1998, pp. 23-27

Abstract

lodine-123-alpha-methyl tyrosine (IMT) allows the investigation of amino acid transport rate in brain neoplasms. It was the aim of this study to evaluate the potential of IMT-SPECT to diagnose the recurrence of gliomas after primary therapy. Methods: Using a triple-headed SPECT camera, the cerebral uptake of IMT was determined in 27 patients 22 mo, on average, after surgical removal of a primary brain tumor. Eighteen patients had suffered from high-grade gliomas, and nine had sufferedfrom low-grade tumors. Four patients were examined before and after surgical revision of a presumed tumor recurrence. A total of 31 studieswere evaluated. The final diagnosis was based on prospective clinicopathological follow-up. Recurrence was diagnosed in 23 cases, with marked clinical deterioration occurring 3.1 mo, on average, after SPECT, and was confirmed by histopathology in 14 instances. Eight cases were free of recurrence, as evidenced by inconspicuous clinical follow-up, ranging from 6 mo to 17 mo after SPECT in seven cases, and by clinical course and histopathology in the remaining subject. Results: Patients with recurrence had significantly higher ratios of IMT uptake in the tumor area to that in a background region than did patients without recurrence (2.27 +/- 0.59 compared to 1.47 +/- 0.29; p < 0.002). The bestcutoff level of the IMT uptake ratio in the differentiation between recurrence and benign posttherapeutic lesion was 1.8. Using this study-specific discrimination threshold, the sensitivity and specificity of IMT-SPECT for detecting glioma recurrence were 18 of 23 (78%) and 8 of8 (100%), respectively. The area under the binormal receiver operating characteristic curve, fitted to the data, was 0.90 +/- 0.06. Conclusion: lodine-123-alpha-methyl tyrosine-SPECT is a promising new tool inthe follow-up of patients with gliomas after primary therapy.

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Documento generato il 24/01/21 alle ore 03:57:38