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Titolo:
SUPPRESSION OF RENAL SYMPATHETIC-NERVE ACTIVITY DURING PORTAL-VEIN INFUSION OF HYPERTONIC SALINE
Autore:
NISHIDA Y; SUGIMOTO I; MORITA H; MURAKAMI H; HOSOMI H; BISHOP VS;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT PHYSIOL,7703 FLOYD CURL DR SAN ANTONIO TX 78284 UNIV TEXAS,HLTH SCI CTR,DEPT PHYSIOL SAN ANTONIO TX 78284 GIFU UNIV,SCH MED,DEPT PHYSIOL GIFU 500 JAPAN KAGAWA MED SCH,DEPT PHYSIOL,KITA KU KAGAWA 76107 JAPAN
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 1, volume: 43, anno: 1998,
pagine: 97 - 103
SICI:
0363-6119(1998)43:1<97:SORSAD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; AREA POSTREMA; CONSCIOUS RABBITS; PHARMACOLOGICAL CHARACTERIZATION; REFLEX PLAYS; RAT; VASOPRESSIN; DOGS; OSMORECEPTORS; BARORECEPTORS;
Keywords:
SODIUM CHLORIDE; HEPATORENAL REFLEX; VASOPRESSIN; NEUROHUMORAL INTERACTION; AREA POSTREMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
Y. Nishida et al., "SUPPRESSION OF RENAL SYMPATHETIC-NERVE ACTIVITY DURING PORTAL-VEIN INFUSION OF HYPERTONIC SALINE", American journal of physiology. Regulatory, integrative and comparative physiology, 43(1), 1998, pp. 97-103

Abstract

Sodium ions absorbed from the intestine are postulated to act on the liver to reflexly suppress renal sympathetic nerve activity (RSNA), resulting in inhibition of sodium reabsorption in the kidney. To test the hypothesis that the renal sympathoinhibitory response to portal venous NaCl infusion involves an action of arginine vasopressin (AVP) at the area postrema, we examined the effects of portal venous infusion ofhypertonic NaCl on RSNA before and after lesioning of the area postrema (APL) or after pretreatment with an AVP V-1 receptor antagonist (AVPX). Rabbits were chronically instrumented with portal and femoral venous catheters, femoral arterial catheters, and renal nerve electrodes. Portal venous infusion of 9.0% NaCl (0.02, 0.05, 0.10, and 0.15 ml.kg(-1).min(-1) of 9.0% NaCl for 10 min) produced a dose-dependent suppression of RSNA (-12 +/- 3, -34 +/- 3, -62 +/- 5, and 80 +/- 2%, respectively) that was greater than that produced by femoral vein infusion of9.0% NaCl (2 +/- 3, -3 +/- 2, -12 +/- 4, and -33 +/- 3%, respectively). The suppression of RSNA produced by portal vein infusion of 9.0% NaCl was partially reversed by pretreatment with AVPX (-9 +/- 3, -20 +/-3, -41 +/- 4, and -55 +/- 4%, respectively) and by APL (-11 +/- 2, -25 +/- 2, -49 +/- 3, and -59 +/- 6%, respectively). There were no significant differences between the effects of AVPX and APL, and the effectof APL was not augmented by AVPX. These results indicate that the suppression of RSNA due to portal venous infusion of 9.0% NaCl involves an action of AVP via the area postrema.

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Documento generato il 03/07/20 alle ore 01:15:37